Paige G D
Department of Ophthalmology, U490, University of California, San Francisco 94143.
Rev Oculomot Res. 1985;1:145-53.
The vestibulo-ocular reflex (VOR), the optokinetic reflex (OKR), and their interactions were studied before and after unilateral horizontal canal (HC) plug. Two independent changes occur in the VOR following HC plug: (a) a drop in VOR gain which recovers rapidly, provided that monkeys are permitted normal visual-vestibular interaction (VVI); and (b) a deterioration in response characteristics at low frequencies, consistent with a decrease in effective VOR time constant. The latter occurs regardless of VVI and VOR gain recovery and progresses over several days. The time constant may recover, but only after several months. OKR responses are in keeping with the notion that they represent a combination of fast and slow processes. Results after HC plug suggest that the gain of the slow OKR process rises along with that of the VOR. Response characteristics of synergistic and antagonistic VVI behave as linear combinations of VOR and OKR response characteristics both before and after HC plug. Changes in VVI arising after HC plug simply reflect modifications in VOR and OKR response characteristics.
在单侧水平半规管（HC）堵塞前后，对前庭眼反射（VOR）、视动反射（OKR）及其相互作用进行了研究。HC堵塞后，VOR会出现两个独立的变化：（a）VOR增益下降，只要猴子被允许进行正常的视觉-前庭相互作用（VVI），增益会迅速恢复；（b）低频响应特性变差，这与有效VOR时间常数的降低一致。后者的出现与VVI和VOR增益恢复无关，且会在数天内逐渐发展。时间常数可能会恢复，但要在数月之后。OKR反应符合它们代表快速和慢速过程组合的观点。HC堵塞后的结果表明，慢速OKR过程的增益与VOR的增益一起上升。协同和拮抗VVI的反应特性在HC堵塞前后均表现为VOR和OKR反应特性的线性组合。HC堵塞后出现的VVI变化仅仅反映了VOR和OKR反应特性的改变。
