Sugarbaker Paul H
Program in Peritoneal Surface Malignancy, Washington Cancer Institute, Washington, DC, USA.
J Surg Oncol. 2024 Nov;130(6):1163-1172. doi: 10.1002/jso.27913. Epub 2024 Oct 13.
Cytoreductive surgery with HIPEC has definite application to the management of selected patients with peritoneal metastases. Patients who profit most have a complete cytoreductive surgery. Higher-grade tumors such as colorectal cancer, gastric cancer, and ovarian malignancy are benefited by CRS and HIPEC only under limited circumstances. High-grade tumor invades subperitoneal lymphatics where HIPEC is not effective. Options to traditional HIPEC for treatment of invasive intraabdominal malignancies with peritoneal metastases must be explored.
细胞减灭术联合腹腔内热灌注化疗（HIPEC）在特定腹膜转移患者的治疗中具有明确的应用价值。获益最大的患者接受了完全细胞减灭术。只有在有限的情况下，诸如结直肠癌、胃癌和卵巢恶性肿瘤等高分级肿瘤才能从细胞减灭术和腹腔内热灌注化疗中获益。高分级肿瘤侵犯腹膜下淋巴管，而腹腔内热灌注化疗对此无效。必须探索传统腹腔内热灌注化疗之外的其他治疗方法，用于治疗伴有腹膜转移的侵袭性腹腔内恶性肿瘤。
