比较中度创伤性脑损伤后脑组织饱和度和脑网络水摄取量。

Comparison of Cerebral Saturation and Brain Net Water Uptake After Moderate Traumatic Brain Injury.

机构信息

Department of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

Department of Physiology, Saratov State University, Saratov, Russia.

出版信息

Adv Exp Med Biol. 2024;1463:57-60. doi: 10.1007/978-3-031-67458-7_10.

DOI:10.1007/978-3-031-67458-7_10

PMID:39400800

Abstract

UNLABELLED

The aim was to study the relationship between net water uptake (NWU) and cerebral oxygenation in patients with posttraumatic ischaemia (PTI) foci after moderate traumatic brain injury (moTBI).

MATERIALS AND METHODS

Perfusion computed tomography (PCT) was performed for 72 patients with PTI foci after moTBI in 2013-2022. The mean age of the patients was 32.7 ± 12.5 years (from 18 to 65 years), 25 women and 47 men. Cerebral tissue oxygen saturation (SctO) was evaluated using Fore-Sight 2030 (CAS Medical Systems Inc., USA) in the region of the frontal lobe pole (FLP). NWU was calculated from non-contrast CT. Data are shown as a median [interquartile range]. P < 0.05 was considered statistically significant.

RESULTS

SctO in FLP varied within the range from 61% to 88%. It was 62% [55.4;72.1] over the lesion frontal lobe with PTI and 64% [58.5;73.7] over the opposite FLP side. The average NWU in the FLP cortex on the PTI side was 4.98% [2.21;7.39]. In the case when there were no focal injuries in the frontal lobes, SctO was significantly correlated with higher NWU (R = -0.780, p < 0.00001).

CONCLUSIONS

The cerebral oxygen tissue saturation correlates with net water uptake in patients with PTI after moTBI (p < 0.005).

摘要

目的

研究中度创伤性脑损伤（moTBI）后创伤性脑缺血（PTI）病灶患者净水分摄取（NWU）与脑氧合之间的关系。

材料和方法

2013 年至 2022 年，对 72 例 PTI 病灶 moTBI 患者进行了灌注 CT（PCT）检查。患者平均年龄为 32.7±12.5 岁（18 至 65 岁），其中女性 25 例，男性 47 例。使用 Fore-Sight 2030（美国 CAS Medical Systems Inc.）在额极区（FLP）评估脑组织氧饱和度（SctO）。从非增强 CT 计算 NWU。数据显示为中位数[四分位数范围]。P<0.05 被认为具有统计学意义。

结果

FLP 中的 SctO 范围在 61%至 88%之间。病变额叶有 PTI 时为 62%[55.4；72.1]，对侧 FLP 侧为 64%[58.5；73.7]。PTI 侧额极皮质的平均 NWU 为 4.98%[2.21；7.39]。在没有额叶局灶性损伤的情况下，SctO 与较高的 NWU 显著相关（R=-0.780，p<0.00001）。