Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, HangKong Road 13, Wuhan, 430030, Hubei, China.
Key Laboratory of Environment and Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Environ Geochem Health. 2024 Oct 14;46(11):475. doi: 10.1007/s10653-024-02261-3.
Previous studies about metal exposures and bone mineral density (BMD) have mainly focused on individual metals. The objective of this study was to explore the association of single and multiple metal exposures with BMD among Chinese adults. We recruited 2922 participants from Tongji Hospital in Wuhan, China. The urinary concentrations of 21 metals were measured by the inductively coupled plasma mass spectrometer. BMD was measured using dual-energy X-ray absorptiometry. We applied linear regression and Bayesian kernel machine regression (BKMR) to examine the association of single and multiple metal exposure with BMD, respectively. The linear regression model showed that cadmium (Cd) and strontium (Sr) were associated with lower BMD (all P-trend < 0.05). Compared with the lowest quantiles, the β (95% CI) of BMD in the highest quartile of Cd and Sr was - 0.032 (- 0.049, - 0.016) and - 0.033 (- 0.049, - 0.018), respectively. The BKMR results showed that co-exposure to 21 metals was negatively associated with BMD among the total participants and males. Our study suggested that exposure to multiple metals was negatively associated with BMD, particularly among males. More prospective studies are needed to identify these associations and reveal the underlying mechanisms.
先前关于金属暴露与骨密度（BMD）的研究主要集中在单个金属上。本研究旨在探讨中国成年人单一和多种金属暴露与 BMD 的关系。我们从中国武汉同济医院招募了 2922 名参与者。采用电感耦合等离子体质谱法测定 21 种金属的尿浓度。采用双能 X 射线吸收法测量 BMD。我们分别应用线性回归和贝叶斯核机器回归（BKMR）来检验单一和多种金属暴露与 BMD 的关系。线性回归模型显示，镉（Cd）和锶（Sr）与较低的 BMD 相关（均 P-趋势<0.05）。与最低四分位数相比，Cd 和 Sr 最高四分位数的 BMD 的β（95%CI）分别为-0.032（-0.049，-0.016）和-0.033（-0.049，-0.018）。BKMR 结果表明，在总参与者和男性中，21 种金属的共同暴露与 BMD 呈负相关。本研究表明，多种金属暴露与 BMD 呈负相关，尤其是在男性中。需要更多的前瞻性研究来确定这些关联并揭示潜在的机制。
