Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Department of Medicine, University of Helsinki, Helsinki, Finland.
Clin Exp Dent Res. 2024 Dec;10(6):e70023. doi: 10.1002/cre2.70023.
The aim of this study was to investigate whether periodontal condition is associated with the development of impaired glucose tolerance (IGT).
This study was based on a subpopulation of a cohort of persons born in 1935 and living in Oulu, Finland, on October 1, 1990. The participants were normoglycemic (no previously diagnosed diabetes mellitus and a 2-h oral glucose tolerance test [OGTT] blood glucose < 7.8 mmol/L) in the baseline examinations (1990-1992) and had fasting blood glucose < 7.0 mmol/L in the follow-up examinations (2007-2008) (n = 225). The outcome was IGT on follow-up, measured by a blood glucose level of ≥ 7.8 mmol/L after OGTT. The exposure was the periodontal condition at baseline categorized into four groups: 0, 1-6, ≥ 7 sites with deepened (≥ 4 mm) periodontal pockets, and edentulousness.
A total of 23% of the participants developed IGT. The adjusted incidence rate ratios with 95% confidence intervals (CI) for dentate participants with 1-6 sites and ≥ 7 sites with deepened periodontal pockets, and edentate participants (reference category dentate participants without deepened periodontal pockets) were 1.5 (95% CI, 0.6-4.0), 1.8 (95% CI, 0.7-4.4), and 1.6 (95% CI, 0.6-4.0), respectively.
Poor periodontal condition may predispose individuals to IGT; however, further studies on this matter are warranted.
本研究旨在探讨牙周状况是否与葡萄糖耐量受损（IGT）的发生有关。
本研究基于出生于 1935 年、1990 年 10 月 1 日居住在芬兰奥卢的队列人群的一个亚群。参与者在基线检查（1990-1992 年）时血糖正常（无先前诊断的糖尿病和 2 小时口服葡萄糖耐量试验[OGTT]血糖<7.8mmol/L），且在随访检查（2007-2008 年）时空腹血糖<7.0mmol/L（n=225）。IGT 的结果是在随访时通过 OGTT 后血糖水平≥7.8mmol/L 来测量的。暴露是基线时的牙周状况，分为四组：0、1-6、≥7 个部位有加深（≥4mm）的牙周袋和无牙。
共有 23%的参与者发展为 IGT。调整后的发病风险比（95%可信区间[CI]）为有 1-6 个部位和≥7 个部位有加深牙周袋的有牙参与者以及无牙参与者（无加深牙周袋的有牙参与者为参考类别）分别为 1.5（95%CI，0.6-4.0）、1.8（95%CI，0.7-4.4）和 1.6（95%CI，0.6-4.0）。
较差的牙周状况可能使个体易患 IGT；然而，需要进一步研究这一问题。
