Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
PLoS One. 2021 Jun 29;16(6):e0253769. doi: 10.1371/journal.pone.0253769. eCollection 2021.
We investigated the association between oral hygiene indicators of periodontitis, tooth loss, and tooth brushing on the longitudinal fasting glucose level in non-diabetic subjects. Using a nationwide health screening database in Korea, we included non-diabetic individuals who received a health screening program with oral health check in 2009-2010. We constructed a linear mixed model for the longitudinal data of fasting glucose from the baseline to 2015. During the 4.84-year of median follow-up, 91,963 individuals (mean age 56.2 at baseline) underwent 392,780 health examinations with fasting glucose level (mmol/L). The presence of periodontitis was 39.3%. In the multivariate linear mixed analysis, periodontitis was related with increased fasting glucose levels (β = 0.0084, standard error = 0.0035, p = 0.018). Similarly, tooth loss was associated with increased level of fasting glucose (β = 0.0246, standard error = 0.0038, p < 0.001). Compared with tooth brushing ≤2 times/day, tooth brushing ≥3 times/day was associated with decreased fasting glucose levels (β = -0.0207, standard error = 0.0033, p < 0.001). Our data showed that periodontitis and tooth loss were associated with increased fasting glucose levels in non-diabetic individuals. The study findings imply that frequent tooth brushing may reduce fasting glucose levels. Further research is needed to determine the effect of periodontal intervention on glycemic control.
我们研究了牙周炎的口腔卫生指标、牙齿缺失和刷牙与非糖尿病患者空腹血糖水平的纵向关系。我们使用了韩国全国健康筛查数据库，纳入了 2009-2010 年接受过健康筛查计划和口腔健康检查的非糖尿病个体。我们构建了一个线性混合模型，用于分析从基线到 2015 年的空腹血糖纵向数据。在中位数为 4.84 年的随访期间，91963 名个体（基线时平均年龄为 56.2 岁）接受了 392780 次空腹血糖检查（mmol/L）。牙周炎的患病率为 39.3%。在多变量线性混合分析中，牙周炎与空腹血糖水平升高相关（β=0.0084，标准误=0.0035，p=0.018）。同样，牙齿缺失与空腹血糖水平升高相关（β=0.0246，标准误=0.0038，p<0.001）。与每天刷牙≤2 次相比，每天刷牙≥3 次与空腹血糖水平降低相关（β=-0.0207，标准误=0.0033，p<0.001）。我们的数据表明，牙周炎和牙齿缺失与非糖尿病个体的空腹血糖水平升高有关。研究结果表明，频繁刷牙可能会降低空腹血糖水平。需要进一步研究来确定牙周干预对血糖控制的影响。
