Davis J R
Cancer Genet Cytogenet. 1986 Jan 1;19(1-2):123-7. doi: 10.1016/0165-4608(86)90379-1.
Abnormalities of fertilization are responsible for two types of placental moles. This synopsis of the two syndromes includes definition, relative incidence, mechanism of fertilization, and clinical course. Controversy regarding the comparative course has diminished with the recognition that partial moles can have sequelae requiring chemotherapy, although less frequently than complete moles. An important subgroup of complete moles is dispermic and heterozygous (usually 46,XY), and these have a disproportionately high rate of postmolar complications. Recommendations are made for routine cytogenetic study of moles in order to foster precision in classification and search for heterozygosity in complete moles. A technique is given for isolation and promotion of growth in vitro of molar trophoblastic cells. Additional information about the two syndromes is needed, a challenge for cytogeneticists.
受精异常是两种胎盘绒毛膜瘤的病因。这两种综合征的概述包括定义、相对发病率、受精机制和临床病程。随着人们认识到部分性葡萄胎可能有需要化疗的后遗症，尽管其频率低于完全性葡萄胎，但关于比较病程的争议已经减少。完全性葡萄胎的一个重要亚组是双精子受精且杂合子型（通常为46,XY），这些病例的葡萄胎后并发症发生率异常高。建议对葡萄胎进行常规细胞遗传学研究，以提高分类的准确性并寻找完全性葡萄胎中的杂合性。文中给出了一种分离和促进葡萄胎滋养层细胞体外生长的技术。关于这两种综合征还需要更多信息，这对细胞遗传学家来说是一项挑战。
