Dunnick J K, Boorman G A, Haseman J K, Langloss J, Cardy R H, Manus A G
Cancer Res. 1986 Jan;46(1):264-70.
Dimethyl hydrogen phosphite (DMHP), an intermediate in the production of insecticides or herbicides, was administered by p.o. gavage for 2 yr to male Fischer 344/N rats and male and female B6C3F1 mice at doses of 0, 100, or 200 mg/kg and to female Fischer 344/N rats at doses of 0, 50 or 100 mg/kg. Dose related toxicity was seen in the lungs of treated male and female rats. The lung lesions were most prevalent in the high dose male rat group which received a dose twice that given to the high dose female rats. Lung lesions included alveolar epithelial hyperplasia, chemically related pneumonia, alveolar-bronchiolar adenoma, alveolar-bronchiolar carcinoma, and squamous cell carcinoma. DMHP also caused neoplastic and nonneoplastic lesions of the forestomach in male rats; a similar but less pronounced effect was observed in female rats. Nonneoplastic lesions associated with administration of DMHP included mineralization of the cerebellum in male rat and focal calcification of the testis in male mice. Under the conditions of this study, there was clear evidence for carcinogenicity for male rats, equivocal evidence for carcinogenicity in female rats, and no evidence for carcinogenicity in either male or female mice. DMHP caused the highest incidence of lung tumors in the male rat of all chemicals studied to date in the National Cancer Institute-National Toxicology Program Carcinogenesis Testing Program.
亚磷酸二甲酯（DMHP）是杀虫剂或除草剂生产中的一种中间体，通过口服灌胃的方式，以0、100或200mg/kg的剂量给予雄性Fischer 344/N大鼠和雄性及雌性B6C3F1小鼠两年，并以0、50或100mg/kg的剂量给予雌性Fischer 344/N大鼠。在接受治疗的雄性和雌性大鼠的肺部观察到剂量相关的毒性。肺部病变在高剂量雄性大鼠组中最为普遍，该组接受的剂量是高剂量雌性大鼠的两倍。肺部病变包括肺泡上皮增生、化学相关性肺炎、肺泡-细支气管腺瘤、肺泡-细支气管癌和鳞状细胞癌。DMHP还导致雄性大鼠前胃出现肿瘤性和非肿瘤性病变；在雌性大鼠中观察到类似但不太明显的影响。与DMHP给药相关的非肿瘤性病变包括雄性大鼠小脑矿化和雄性小鼠睾丸局灶性钙化。在本研究条件下，有明确证据表明雄性大鼠具有致癌性，雌性大鼠致癌性证据不明确，雄性和雌性小鼠均无致癌性证据。在国家癌症研究所-国家毒理学计划致癌性测试项目中，DMHP在所有已研究的化学物质中导致雄性大鼠肺部肿瘤的发生率最高。
