Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China;NHC Key Laboratory of Etiology and Epidemiology (Harbin Medical University), Key Laboratory of Etiology and Epidemiology, Education Bureau of Heilongjiang Province, Harbin Medical University, Harbin 150081, China.
Biomed Environ Sci. 2024 Sep 20;37(9):1056-1066. doi: 10.3967/bes2024.109.
To analyze the epidemiological characteristics and epidemic situation of children with Kashin-Beck disease (KBD) in China, and provide the basis for formulating prevention and control measures.
Fixed-point monitoring, moving-point monitoring, and full coverage of monitoring were promoted successively from 1990 to 2023. Some children (7-12 years old) underwent clinical and right-hand X-ray examinations every year. According to the KBD diagnosis criteria, clinical and X-ray assessments were used to confirm the diagnosis.
In 1990, the national KBD detectable rate was 21.01%. X-ray detection decreased to below 10% in 2003 and below 5% in 2007. Between 2010 and 2018, the prevalence of KBD in children was less than 0.4%, which fluctuated at a low level, and has decreased to 0% since 2019. Spatial epidemiological analysis indicated a spatial clustering of adult patients prevalence rate in the KBD areas.
The evaluation results of the elimination of KBD in China over the last 5 years showed that all villages in the monitored areas have reached the elimination standard. While the adult KBD patients still need for policy consideration and care.
分析中国大骨节病（KBD）患儿的流行特征和疫情，为制定防控措施提供依据。
1990 年至 2023 年，先后推广定点监测、移动监测和全覆盖监测。每年对部分儿童（7-12 岁）进行临床和右手 X 线检查。根据 KBD 诊断标准，采用临床和 X 线评估进行诊断。
1990 年全国 KBD 检出率为 21.01%。2003 年 X 射线检出率降至 10%以下，2007 年降至 5%以下。2010 年至 2018 年，儿童 KBD 患病率低于 0.4%，呈低水平波动，自 2019 年以来已降至 0%。空间流行病学分析表明，KBD 地区成人患者患病率存在空间聚集。
对中国过去 5 年消除 KBD 的评价结果表明，监测地区所有村庄均达到消除标准。而成年 KBD 患者仍需政策考虑和关怀。
