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五岁男童对钆基磁共振对比剂发生过敏反应:一例报告。

A five-year-old boy with anaphylaxis reaction to gadolinium-based MR contrast medium: a case report.

机构信息

Department of Orthopedic Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, 50612, Gyeongsangnam-do, Korea.

Department of Orthopedic Surgery, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, Korea.

出版信息

BMC Pediatr. 2024 Oct 15;24(1):660. doi: 10.1186/s12887-024-05144-9.

DOI:10.1186/s12887-024-05144-9
PMID:39402496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11476709/
Abstract

Magnetic resonance imaging (MRI) is one of the most widely used tests in orthopedic areas. Gadolinium-based magnetic resonance (MR) contrast media are commonly used for MRI tests. They are known to be safe with little side effects and low incidence of acute adverse reactions. Although not common, immediate hypersensitivity reaction can occur in some patients after administration of gadolinium-based MR contrast media, causing skin rash, vascular edema, dyspnea, abdominal pain, hypotension, altered mental status, cardiopulmonary arrest, and even death. During a knee joint MRI test in a 5-year-old boy, anaphylaxis, a serious symptom, occured after injecting gadolinium-based MR contrast medium. Here we report this case along with a literature review.

摘要

磁共振成像(MRI)是骨科领域最常用的检查之一。钆基磁共振(MR)对比剂常用于 MRI 检查。它们被认为是安全的,副作用小,急性不良反应发生率低。虽然不常见,但在一些患者中,在给予钆基 MR 对比剂后可能会发生即刻超敏反应,导致皮疹、血管性水肿、呼吸困难、腹痛、低血压、意识改变、心肺骤停,甚至死亡。在一名 5 岁男孩的膝关节 MRI 检查中,在注射钆基 MR 对比剂后发生了严重的过敏反应。我们在此报告该病例并进行文献复习。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4254/11476709/f10648b77165/12887_2024_5144_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4254/11476709/59af2ff46327/12887_2024_5144_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4254/11476709/f10648b77165/12887_2024_5144_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4254/11476709/59af2ff46327/12887_2024_5144_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4254/11476709/f10648b77165/12887_2024_5144_Fig3_HTML.jpg

相似文献

1
A five-year-old boy with anaphylaxis reaction to gadolinium-based MR contrast medium: a case report.五岁男童对钆基磁共振对比剂发生过敏反应:一例报告。
BMC Pediatr. 2024 Oct 15;24(1):660. doi: 10.1186/s12887-024-05144-9.
2
Incidence of immediate gadolinium contrast media reactions.即刻型钆对比剂不良反应发生率。
AJR Am J Roentgenol. 2011 Feb;196(2):W138-43. doi: 10.2214/AJR.10.4885.
3
Immediate hypersensitivity reaction to gadolinium-based MR contrast media.立即对钆基磁共振对比剂产生超敏反应。
Radiology. 2012 Aug;264(2):414-22. doi: 10.1148/radiol.12112025. Epub 2012 May 1.
4
Gadolinium-based contrast agent anaphylaxis, a unique presentation of acute abdominal pain.钆基造影剂过敏反应,一种急性腹痛的独特表现。
Am J Emerg Med. 2016 Aug;34(8):1737.e1-2. doi: 10.1016/j.ajem.2015.12.063. Epub 2015 Dec 23.
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Safety of magnetic resonance contrast media.磁共振造影剂的安全性。
Top Magn Reson Imaging. 2001 Aug;12(4):309-14. doi: 10.1097/00002142-200108000-00007.
6
Adverse reactions to gadolinium contrast media: a review of 36 cases.钆对比剂的不良反应:36例病例回顾
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Hypersensitivity reactions to gadolinium-based contrast agents.对钆基造影剂的超敏反应。
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Late Diagnosis of Anaphylactic Reaction to Gadolinium-Based Contrast Media by Skin Tests 10 Years After Onset.迟发性钆对比剂过敏反应的皮肤试验诊断:起病10年后的病例报告
J Investig Allergol Clin Immunol. 2018 Jun;28(3):203-205. doi: 10.18176/jiaci.0240.
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Acute adverse reactions to magnetic resonance contrast media--gadolinium chelates.磁共振造影剂——钆螯合物的急性不良反应
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Which study when? Iodinated contrast-enhanced CT versus gadolinium-enhanced MR imaging.何时进行哪种研究?碘对比剂增强CT与钆增强磁共振成像。
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本文引用的文献

1
Statement from the ACR Committee on Drugs and Contrast Media on the Intravenous Iodinated Contrast Media Shortage.美国放射学会药物与造影剂委员会关于静脉注射碘化造影剂短缺的声明。
J Am Coll Radiol. 2022 Jul;19(7):834-835. doi: 10.1016/j.jacr.2022.05.006. Epub 2022 May 20.
2
Hypersensitivity to Gadolinium-Based Contrast Media.对钆基造影剂过敏
Front Allergy. 2022 Mar 17;3:813927. doi: 10.3389/falgy.2022.813927. eCollection 2022.
3
Allergic-like Hypersensitivity Reactions to Gadolinium-based Contrast Agents: An 8-year Cohort Study of 154 539 Patients.
对钆基造影剂的类过敏超敏反应:一项针对154539名患者的8年队列研究。
Radiology. 2022 May;303(2):329-336. doi: 10.1148/radiol.210545. Epub 2022 Feb 22.
4
Delayed anaphylaxis due to gadolinium- A rare clinical scenario.钆引起的迟发性过敏反应——一种罕见的临床情况。
Radiol Case Rep. 2021 Sep;16(9):2522-2525. doi: 10.1016/j.radcr.2021.06.010. Epub 2021 Jul 3.
5
Acute Reactions to Gadolinium-Based Contrast Agents in a Pediatric Cohort: A Retrospective Study of 16,237 Injections.儿童队列中钆类造影剂的急性反应:16237 次注射的回顾性研究。
AJR Am J Roentgenol. 2021 May;216(5):1363-1369. doi: 10.2214/AJR.20.23602. Epub 2020 Jul 20.
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Subsequent MRI of pediatric patients after an adverse reaction to Gadolinium-based contrast agents.儿童患者在出现钆基造影剂不良反应后的后续 MRI。
PLoS One. 2020 Apr 3;15(4):e0230781. doi: 10.1371/journal.pone.0230781. eCollection 2020.
7
Time to revisit the definition and clinical criteria for anaphylaxis?是时候重新审视过敏反应的定义和临床标准了?
World Allergy Organ J. 2019 Oct 31;12(10):100066. doi: 10.1016/j.waojou.2019.100066. eCollection 2019 Oct.
8
Immediate Allergic Reactions to Gadolinium-based Contrast Agents: A Systematic Review and Meta-Analysis.钆基造影剂的速发型过敏反应:一项系统评价与荟萃分析
Radiology. 2018 Feb;286(2):731. doi: 10.1148/radiol.2017174037.
9
Immediate hypersensitivity reaction to gadolinium-based MR contrast media.立即对钆基磁共振对比剂产生超敏反应。
Radiology. 2012 Aug;264(2):414-22. doi: 10.1148/radiol.12112025. Epub 2012 May 1.
10
Frequency and severity of acute allergic-like reactions to gadolinium-containing i.v. contrast media in children and adults.儿童和成人中对含钆静脉造影剂急性过敏样反应的发生率和严重程度。
AJR Am J Roentgenol. 2007 Dec;189(6):1533-8. doi: 10.2214/AJR.07.2554.