Department of Respiratory Medicine, The Affiliated General Hospital Binhai Hospital of Tianjin Medical University, Tianjin, 300456, China.
Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
BMC Womens Health. 2024 Oct 14;24(1):562. doi: 10.1186/s12905-024-03396-2.
Though the survival of breast cancer (BC) patients with malignant pleural effusion (MPE) has been studied, this has not been specifically studied in the luminal B subtype. Therefore, this study investigated the characteristics and survival of luminal B-BC patients presenting with MPE.
We retrospectively analyzed 141 patients diagnosed with postoperative advanced Luminal B breast cancer, including 54 cases with MPE and 87 cases without MPE at the Tianjin Cancer Hospital from January 2012 to January 2015. We assessed the clinical characteristics between the groups.
The mean age of all patients was 47 years, with no significant difference between the two groups. Altogether, 29 (33%), 24 (28%), 28 (32%), 45 (52%), and 10 (11%) patients had lung, liver, bone, lymph node, and chest wall metastases, respectively. In addition. The difference in overall survival between the two groups was not significant (P>0.05). However, cox regression analysis showed that only the tumor clinical stage at initial diagnosis was related to short overall survival. Further, we conducted a subgroup analysis and found that the higher the clinical stage at initial diagnosis in age < 50 years patients, the shorter the overall survival, while age > 50 years patients was not. (P < 0.05).
There was no difference in the overall survival between luminal B-BC patients with MPE and those without. Clinical stages at initial diagnosis were an independent prognostic factor for age < 50 years luminal B BC with MPE overall survival. Our results may help clinicians make positive decisions regarding personalized treatment of luminal B-BC with MPE.
尽管已经研究了患有恶性胸腔积液（MPE）的乳腺癌（BC）患者的生存情况，但在腔 B 型亚型中尚未对此进行专门研究。因此，本研究调查了表现出 MPE 的腔 B-BC 患者的特征和生存情况。
我们回顾性分析了 2012 年 1 月至 2015 年 1 月在天津市肿瘤医院诊断为术后晚期腔 B 型乳腺癌的 141 例患者，包括 54 例有 MPE 和 87 例无 MPE。我们评估了两组之间的临床特征。
所有患者的平均年龄为 47 岁，两组之间无显著差异。共有 29 例（33%）、24 例（28%）、28 例（32%）、45 例（52%）和 10 例（11%）患者分别发生肺、肝、骨、淋巴结和胸壁转移。此外，两组之间的总生存差异无统计学意义（P>0.05）。但是，Cox 回归分析显示，仅初始诊断时的肿瘤临床分期与总生存时间短有关。此外，我们进行了亚组分析，发现初始诊断时临床分期越高的年龄<50 岁患者的总生存时间越短，而年龄>50 岁患者则不然。（P<0.05）。
有 MPE 和无 MPE 的腔 B-BC 患者的总生存时间无差异。初始诊断时的临床分期是年龄<50 岁有 MPE 的腔 B 型 BC 总生存的独立预后因素。我们的结果可能有助于临床医生对有 MPE 的腔 B-BC 做出积极的个体化治疗决策。
