Hypotensive response in spontaneously hypertensive rats following microinjection of alpha-methylnoradrenaline in the caudal brain-stem.
作者信息
Zandberg P, de Jong W
出版信息
Neurosci Lett. 1979 Sep;14(1):119-22. doi: 10.1016/0304-3940(79)95356-4.
PMID:394027
Abstract
Local microinjection of 1.25 nmol (-)-alpha-methylnoradrenaline in the A2-region of the nucleus tractus solitarii (NTS) caused a decrease of blood pressure and heart rate in both spontaneous hypertensive rats (SHR) and Wistar-Kyoto (W/K) rats. Although the maximal responses in both strains did not differ, the decrease in blood pressure lasted longer in the SHR. These results do not support the concept of a diminished sensitivity of catecholaminergic receptors in the NTS of SHR to alpha-methylnoradrenaline.
摘要
相似文献
1
Hypotensive response in spontaneously hypertensive rats following microinjection of alpha-methylnoradrenaline in the caudal brain-stem.
Neurosci Lett. 1979 Sep;14(1):119-22. doi: 10.1016/0304-3940(79)95356-4.
2
Centrally induced hypotension and bradycardia after administration of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat.向大鼠孤束核区域注射α-甲基去甲肾上腺素后引起的中枢性低血压和心动过缓。
Br J Pharmacol. 1976 Dec;58(4):593-8. doi: 10.1111/j.1476-5381.1976.tb08628.x.
3
Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata.儿茶酚胺受体刺激剂在延髓孤束核局部应用后对血压的影响。
Eur J Pharmacol. 1979 Apr 1;55(1):43-56. doi: 10.1016/0014-2999(79)90146-8.
4
alpha-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii.
Eur J Pharmacol. 1975 Jun-Jul;32(02):361-4. doi: 10.1016/0014-2999(75)90305-2.
5
Cardiovascular effects of microinjection of atrial natriuretic factor (ANF) in the nucleus tractus solitarii of spontaneously hypertensive rats.
J Auton Nerv Syst. 1994 Dec 1;50(1):13-20. doi: 10.1016/0165-1838(94)90118-x.
6
Endorphins and the hypotensive response to stimulation of alpha-receptors in the brainstem by alpha-methylnoradrenaline.
Neuropharmacology. 1984 Jun;23(6):643-8. doi: 10.1016/0028-3908(84)90145-x.
7
Role of noradrenaline and serotonin in the central control of blood pressure in normotensive and spontaneously hypertensive rats.去甲肾上腺素和5-羟色胺在正常血压大鼠和自发性高血压大鼠血压中枢控制中的作用
Arch Int Pharmacodyn Ther. 1975 Feb;213(2):272-84.
8
Salusin β Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats.孤束核内的Salusin β通过抑制自发性高血压大鼠延髓头端腹外侧区的交感神经节前神经元活动来降低血压。
Cardiovasc Toxicol. 2016 Jul;16(3):223-34. doi: 10.1007/s12012-015-9330-2.
9
Pressor effect of blocking atrial natriuretic peptide in nucleus tractus solitarii.孤束核中阻断心房利钠肽的升压效应。
Hypertension. 1992 Feb;19(2):198-205. doi: 10.1161/01.hyp.19.2.198.
10
Direct evidence for imidazoline (I1) receptor modulation of ethanol action on norepinephrine-containing neurons in the rostral ventrolateral medulla in conscious spontaneously hypertensive rats.在清醒自发性高血压大鼠中，咪唑啉（I1）受体调节乙醇对延髓头端腹外侧含去甲肾上腺素神经元作用的直接证据。
Alcohol Clin Exp Res. 2007 Apr;31(4):684-93. doi: 10.1111/j.1530-0277.2007.00353.x.
引用本文的文献
1
GPCR dimerization in brainstem nuclei contributes to the development of hypertension.脑干核中的G蛋白偶联受体二聚化促进高血压的发展。
Br J Pharmacol. 2015 May;172(10):2507-18. doi: 10.1111/bph.13074. Epub 2015 Mar 17.
Zotero 插件