Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, New York, NY, United States.
Front Immunol. 2024 Sep 30;15:1417201. doi: 10.3389/fimmu.2024.1417201. eCollection 2024.
The connections between cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) is critical in cancer initiation, progression, metastasis, and therapy resistance, making it a focal point in cancer theragnosis. This review provides a panorama of associations and regulation pathways between CSCs and EMT, highlighting their significance in cancer. The molecular mechanisms underlined EMT are thoroughly explored, including the involvement of key transcription factors and signaling pathways. In addition, the roles of CSCs and EMT in tumor biology and therapy resistance, is further examined in this review. The clinical implications of CSCs-EMT interplay are explored, including identifying mesenchymal-state CSC subpopulations using advanced research methods and developing targeted therapies such as inhibitors and combination treatments. Overall, understanding the reciprocal relationship between EMT and CSCs holds excellent potential for informing the development of personalized therapies and ultimately improving patient outcomes.
癌症干细胞 (CSCs) 与上皮-间充质转化 (EMT) 之间的联系在癌症的发生、进展、转移和治疗耐药中至关重要，使其成为癌症治疗学的重点。本综述提供了 CSCs 与 EMT 之间关联和调控途径的全景图，强调了它们在癌症中的重要性。深入探讨了 EMT 所涉及的分子机制，包括关键转录因子和信号通路的参与。此外，本综述还进一步研究了 CSCs 和 EMT 在肿瘤生物学和治疗耐药性中的作用。探讨了 CSCs-EMT 相互作用的临床意义，包括使用先进的研究方法识别间充质状态 CSC 亚群以及开发靶向治疗方法，如抑制剂和联合治疗。总的来说，理解 EMT 和 CSCs 之间的相互关系具有为制定个性化治疗方案提供信息的巨大潜力，并最终改善患者的治疗效果。
