长时间工作的成年人中，体力活动与肾功能风险的关联。
The association of physical activity with kidney function risk among adults with long working hours.
机构信息
Beijing Institute of Occupational Disease Prevention and Control, Beijing, China.
School of Public Health, Peking University, Beijing, China.
出版信息
Front Endocrinol (Lausanne). 2024 Sep 30;15:1415713. doi: 10.3389/fendo.2024.1415713. eCollection 2024.
INTRODUCTION
Long working hours are likely associated with the decreased of kidney function, while physical activity (PA) was linked to improvements in kidney function. However, whether PA can offset the negative impact of long working hours on kidney function was unclear, which is the focus of this study.
METHODS
A cross-sectional study was conducted. Three approaches were adopted to distinguish the association between long working hours and regular working hours. Moderate to vigorous physical activity (PA) was assessed by a structured questionnaire. eGFR and chronic kidney disease (CKD) or not were utilized to evaluate the kidney function. Linear and logistic regression analyses were conducted to assess the association between weekly working hours, PA, and kidney function.
RESULTS
A total of 18,431 adults were enrolled in this study, including 9981 males (54.2%) and 8450 females (45.8%). The average eGFR was (99.54 ± 17.55 mL/min/1.73 m). The people worked more than 40 h/wk (98.89 ± 17.06 mL/min/1.73 m) had lower eGFR compared to those worked less than 40 h/wk (99.93 ± 17.83 mL/min/1.73 m) ( < 0.05). Individuals working longer hours exhibited lower eGFR ( = -0.772, 95% : -1.241, -0.303, for > 40 h/wk compared to working ≤ 40 h/wk). Engagement in moderate to vigorous PA was associated with higher eGFR values ( = 1.159, 95% : 0.699, 1.619) compared to low PA (< 150 minutes/wk), but this association did not reach statistical significance for the prevalence of CKD. Furthermore, PA was insufficient to reverse the decline of eGFR related to prolonged working hours.
DISCUSSION
Prolonged working hours were associated with a decline in eGFR, while PA was found to have a protective effect on kidney function. However, PA alone may not fully mitigate the negative impact of prolonged working hours on renal health. More robust measures to protect renal function should be implemented to mitigate the damage caused by prolonged working hours.
简介
长时间工作可能与肾功能下降有关，而身体活动（PA）与肾功能改善有关。然而，PA 是否可以抵消长时间工作对肾功能的负面影响尚不清楚，这是本研究的重点。
方法
进行了一项横断面研究。采用三种方法来区分长时间工作和正常工作时间之间的关联。通过结构化问卷评估中度至剧烈体力活动（PA）。肾小球滤过率（eGFR）和慢性肾脏病（CKD）或无用于评估肾功能。线性和逻辑回归分析用于评估每周工作时间、PA 和肾功能之间的关系。
结果
本研究共纳入 18431 名成年人，其中男性 9981 人（54.2%），女性 8450 人（45.8%）。平均 eGFR 为（99.54±17.55）mL/min/1.73m。每周工作时间超过 40 小时的人（98.89±17.06）mL/min/1.73m）的 eGFR 低于每周工作时间少于 40 小时的人（99.93±17.83）mL/min/1.73m）（<0.05）。工作时间较长的个体表现出较低的 eGFR（= -0.772，95%：-1.241，-0.303，对于>40 小时/周与工作≤40 小时/周相比）。与低 PA（<150 分钟/周）相比，进行中度至剧烈 PA 与较高的 eGFR 值相关（=1.159，95%：0.699，1.619），但这一关联在 CKD 的患病率方面没有统计学意义。此外，PA 不足以逆转与长时间工作相关的 eGFR 下降。
讨论
长时间工作与 eGFR 下降有关，而 PA 被发现对肾功能具有保护作用。然而，PA 本身可能无法完全减轻长时间工作对肾脏健康的负面影响。应采取更有力的措施来保护肾功能，以减轻长时间工作造成的损害。
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