Zeng Hongli, Ge Junshang, Meng Yi, Wang Qian, Yang Mei, Zeng Zhaoyang, Xiong Wei, Zu Xuyu
The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, China.
NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, Central South University, Changsha 410078, Hunan, China.
Cancer Drug Resist. 2024 Sep 2;7:31. doi: 10.20517/cdr.2024.57. eCollection 2024.
Drug resistance in tumors constitutes a significant obstacle to tumor therapy. Head and neck squamous cell carcinoma (HNSCC) presents a major challenge due to its deep anatomical location, limited space, and complex structure. These factors complicate surgical procedures and hinder the effectiveness of chemoradiotherapy, leading to poor prognosis and reduced quality of life. However, there is hope in the form of circular RNAs (circRNAs), non-coding RNA molecules with a closed-loop structure that exhibits superior stability and resistance to degradation compared to linear RNAs. Recent advances in high-throughput sequencing and bioinformatics technology revealed that circRNAs participate in tumor proliferation, invasion, migration, and drug resistance. This review aims to summarize current research progress on the involvement of circRNAs in drug resistance of HNSCC and provide valuable insights for the prevention and mitigation of drug resistance in HNSCC.
肿瘤中的耐药性是肿瘤治疗的重大障碍。头颈部鳞状细胞癌（HNSCC）因其解剖位置深、空间有限和结构复杂而带来重大挑战。这些因素使外科手术复杂化，并阻碍放化疗的有效性，导致预后不良和生活质量下降。然而，环状RNA（circRNAs）带来了希望，这是一种具有闭环结构的非编码RNA分子，与线性RNA相比，具有更高的稳定性和抗降解能力。高通量测序和生物信息学技术的最新进展表明，circRNAs参与肿瘤增殖、侵袭、迁移和耐药性。本综述旨在总结circRNAs参与HNSCC耐药性的当前研究进展，并为预防和减轻HNSCC的耐药性提供有价值的见解。
