不同成本的头孢曲松品牌的性能对比：来自坦桑尼亚姆贝亚一家三级转诊医院的见解
performance of cost differentiated ceftriaxone brands against : insights from a tertiary referral hospital in Mbeya, Tanzania.
作者信息
Nsojo Anthony, Mbotwa Christopher, Rweyemamu Linus, Mbwanji Godlove, Wilson Frank, George Lutengano, Mwasomola Davance, Mweya Clement N, Mwakyula Issakwisa
机构信息
Research Unit, Mbeya Zonal Referral Hospital, P. O. Box 419, Mbeya, Tanzania.
Mbeya College of Health and Allied Sciences, University of Dar es Salaam, P. O. Box 608, Mbeya, Tanzania.
出版信息
JAC Antimicrob Resist. 2024 Oct 14;6(5):dlae162. doi: 10.1093/jacamr/dlae162. eCollection 2024 Oct.
BACKGROUND
In Tanzania, ceftriaxone is one of the most commonly prescribed antibiotics. However, there is quite a significant variation in cost for numerous ceftriaxone brands, leading to the perception that pricier options are more effective. Yet, limited empirical data support this perception.
METHODS
Five ceftriaxone brands with a wide price range were tested against a ceftriaxone-sensitive clinical isolate using microdilution and spectrophotometry. Brands were evaluated across a spectrum of concentrations. Bacterial growth inhibition was measured using optical density. Analysis of variance was used to compare the bacterial optical densities among the brands.
RESULTS
All brands were comparable at all tested concentrations, with peak inhibition above 1.95 mg/L.
CONCLUSIONS
Despite significant price disparities, low-cost and high-cost ceftriaxone brands demonstrated similar performance against . This challenges the notion that higher-priced options offer better performance. Further, studies are recommended to validate these findings.
背景
在坦桑尼亚，头孢曲松是最常用的抗生素之一。然而，众多头孢曲松品牌的成本存在相当大的差异，导致人们认为价格较高的产品更有效。然而，仅有有限的实证数据支持这一观点。
方法
使用微量稀释法和分光光度法，针对一种对头孢曲松敏感的临床分离株，对五个价格范围广泛的头孢曲松品牌进行了测试。对各品牌在一系列浓度下进行评估。使用光密度测量细菌生长抑制情况。采用方差分析比较各品牌之间的细菌光密度。
结果
在所有测试浓度下，所有品牌的表现相当，在浓度高于1.95 mg/L时达到最大抑制效果。
结论
尽管价格差异显著，但低成本和高成本的头孢曲松品牌对……表现出相似的性能。这对价格较高的产品性能更佳这一观念提出了挑战。此外，建议开展进一步研究以验证这些发现。
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