Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Department of Pharmacy, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou 310006, China.
Biomater Sci. 2024 Nov 5;12(22):5704-5721. doi: 10.1039/d4bm00959b.
Spinal cord injury is a serious disease of the central nervous system. The electrophysiological properties of the spinal cord that are essential to maintaining neurotransmission can be impaired after the injury. Therefore, electrophysiological evaluation is becoming an important indicator of the injury extent or the therapeutic outcomes by reflecting the potential propagation of neural pathways. On the other hand, the repair of damaged nerves is one of the main goals of spinal cord injury treatment. Growing research interest has been concentrated on developing effective therapeutic solutions to restore the normal electrophysiological function of the injured spinal cord by using conductive materials and/or exerting the merits of electrical stimulation. Accordingly, this review introduces the current common electrophysiological evaluation in spinal cord injury. Then the cutting-edge therapeutic strategies aiming at electrophysiological improvement in spinal cord injury are summarized. Finally, the challenges and future prospects of neural restoration after spinal cord injury are presented.
脊髓损伤是一种严重的中枢神经系统疾病。脊髓的电生理特性对于维持神经传递至关重要，但在损伤后可能会受到损害。因此，电生理评估正成为反映神经通路潜在传播能力的重要指标，可用于评估损伤程度或治疗效果。另一方面，修复受损神经是脊髓损伤治疗的主要目标之一。人们越来越关注通过使用导电材料和/或发挥电刺激的优点，开发有效的治疗方案来恢复损伤脊髓的正常电生理功能。因此，本综述介绍了目前脊髓损伤常用的电生理评估方法。然后总结了旨在改善脊髓损伤电生理的最新治疗策略。最后，提出了脊髓损伤后神经修复的挑战和未来展望。
