Calcineurin inhibitor blocks tolerance by suppressing donor T cell terminal exhaustion after allogeneic hematopoietic cell transplantation.
作者信息
Senjo Hajime, Hashimoto Daigo, Teshima Takanori
出版信息
J Clin Invest. 2024 Oct 15;134(20):e184332. doi: 10.1172/JCI184332.
Abstract
摘要
相似文献
1
Calcineurin inhibitor blocks tolerance by suppressing donor T cell terminal exhaustion after allogeneic hematopoietic cell transplantation.钙调神经磷酸酶抑制剂通过抑制异基因造血细胞移植后供体T细胞的终末耗竭来阻断免疫耐受。
J Clin Invest. 2024 Oct 15;134(20):e184332. doi: 10.1172/JCI184332.
2
Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency.同源造血细胞移植后，因细胞分裂蛋白 8 缺陷导致的常染色体隐性高免疫球蛋白 E 综合征供者骨髓成功植入。
J Allergy Clin Immunol. 2010 Dec;126(6):1304-5.e3. doi: 10.1016/j.jaci.2010.07.034.
3
Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT.钙调磷酸酶抑制剂通过抑制同种异体造血干细胞移植后供体 T 细胞的终末耗竭来抑制免疫耐受的诱导。
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Mechanisms of transplantation tolerance in animals and humans.动物和人类移植耐受的机制。
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5
Graft Engineering and Adoptive Immunotherapy: New Approaches to Promote Immune Tolerance After Hematopoietic Stem Cell Transplantation.移植物工程与过继免疫治疗：促进造血干细胞移植后免疫耐受的新方法。
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CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.CD62L- 记忆 T 细胞通过消除小鼠的宿主抗性增强异基因干细胞移植后的 T 细胞再生。
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7
Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance.造血干细胞输注/移植以诱导同种异体移植耐受。
Curr Opin Organ Transplant. 2015 Feb;20(1):49-56. doi: 10.1097/MOT.0000000000000159.
8
Exploiting beneficial alloreactive T cells.利用有益的同种异体反应性T细胞。
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Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen.通过 T 细胞介导的同种异体抗原传递诱导完全错配心脏移植物的移植耐受。
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10
Targeting cells causing split tolerance allows fully allogeneic islet survival with minimal conditioning in NOD mixed chimeras.靶向导致分裂耐受的细胞可使 NOD 混合嵌合体在最小条件下完全异体胰岛存活。
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本文引用的文献
1
Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD.钙调磷酸酶抑制可挽救促进慢性移植物抗宿主病的同种抗原特异性中央记忆 T 细胞亚群。
J Clin Invest. 2024 Jun 3;134(11):e170125. doi: 10.1172/JCI170125.
2
Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT.钙调磷酸酶抑制剂通过抑制同种异体造血干细胞移植后供体 T 细胞的终末耗竭来抑制免疫耐受的诱导。
Blood. 2023 Aug 3;142(5):477-492. doi: 10.1182/blood.2023019875.
3
Developmental Relationships of Four Exhausted CD8 T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.四种耗竭 CD8 T 细胞亚群的发育关系揭示了潜在的转录和表观遗传调控机制。
Immunity. 2020 May 19;52(5):825-841.e8. doi: 10.1016/j.immuni.2020.04.014. Epub 2020 May 11.
4
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1 Stem-like CD8 T Cells during Chronic Infection.在慢性感染期间，具有效应样转录特征的增殖暂态 T 细胞从 PD-1 干性 CD8 T 细胞中出现。
Immunity. 2019 Dec 17;51(6):1043-1058.e4. doi: 10.1016/j.immuni.2019.11.002. Epub 2019 Dec 3.
5
Pharmacokinetic profiles of cyclosporine in rats. Influence of route of administration and dosage.环孢素在大鼠体内的药代动力学特征。给药途径和剂量的影响。
Transplantation. 1985 Nov;40(5):489-93. doi: 10.1097/00007890-198511000-00004.
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