Song Rongrong, Zhang Huanlei, Liang Zhuoping
Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Int Forum Allergy Rhinol. 2024 Dec;14(12):1921-1928. doi: 10.1002/alr.23469. Epub 2024 Oct 15.
OX40/OX40L are costimulatory molecules in the tumor necrosis factor superfamily. Numerous studies have shown that OX40/OX40L are involved in immune regulation, especially in the proliferation and differentiation of T cells and the generation of memory T cells, which play important roles in allergic diseases. In recent years, the use of OX40/OX40L as therapeutic targets for treating T-cell-mediated diseases has attracted the interest of scholars. This paper reviews the role of OX40/OX40L in allergic diseases and the progress in clinical treatments targeting this signaling pathway.
OX40/OX40L是肿瘤坏死因子超家族中的共刺激分子。大量研究表明，OX40/OX40L参与免疫调节，尤其是在T细胞的增殖与分化以及记忆T细胞的产生过程中，而这些在过敏性疾病中发挥着重要作用。近年来，将OX40/OX40L用作治疗T细胞介导疾病的治疗靶点已引起学者们的关注。本文综述了OX40/OX40L在过敏性疾病中的作用以及针对该信号通路的临床治疗进展。
