[镓]镓-LNC1007与2-[氟]氟代脱氧葡萄糖在转移性分化型甲状腺癌患者评估中的比较：一项直接对比研究。
[Ga]Ga-LNC1007 versus 2-[F]FDG in the evaluation of patients with metastatic differentiated thyroid cancer: a head-to-head comparative study.
作者信息
Chen Yun, Zheng Shan, Zang Jie, Shao Zezhong, Tu Dongmei, Liu Qun, Chen Xiaoyuan, Miao Weibing, Zhang Jingjing
机构信息
Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, No 20 Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian Province, China.
Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Changle District, Fuzhou, 350212, China.
出版信息
Eur J Nucl Med Mol Imaging. 2025 Jan;52(2):683-692. doi: 10.1007/s00259-024-06930-4. Epub 2024 Oct 15.
PURPOSE
This head-to-head comparison study aimed to compare the performance of [Ga]Ga-FAPI-RGD (LNC1007) and 2-[F]FDG PET/CT in the evaluation of patients with metastatic differentiated thyroid cancer (mDTC).
METHODS
Ten unexplained hyperthyroglobulinemia (UHTg) patients and 20 patients with definite metastatic lesions of thyroid cancer (DmDTC) were enrolled in the study. All patients underwent both [Ga]Ga-LNC1007 and 2-[F]FDG PET/CT within 1 week. The final diagnosis was based on histopathological results and a comprehensive evaluation of laboratory tests and multimodal imaging characteristics.
RESULTS
In patients with UHTg, [Ga]Ga-LNC1007 PET/CT detected more metastatic lymph nodes (LNs) (17 vs. 15, P = 0.317) and lung lesions (2 vs. 0) than 2-[F]FDG. In patients with DmDTC, [Ga]Ga-LNC1007 PET/CT also detected more true positive lesions than 2-[F]FDG (Total: 133 vs. 103, LN: 20 vs. 15, lung: 18 vs. 10, bone: 87 vs.73). [Ga]Ga-LNC1007 PET/CT demonstrated significantly higher SUVmax (Total: 6.30 vs. 3.84, LN: 8.28 vs. 4.82, Lung: 3.31 vs. 1.49, Bone: 5.73 vs. 3.87, all P < 0.05) and TBR (Total: 6.92 vs. 4.93, LN: 6.48 vs. 4.16, Lung: 5.16 vs. 2.57, Bone: 7.22 vs. 5.41, all P < 0.05) in true positive lesions compared to 2-[F]FDG. Specifically, the sensitivity of [Ga]Ga-LNC1007 PET/CT was higher than that of 2-[F]FDG in detecting lung and bone metastases (94.7% vs. 52.6% and 100% vs. 83.9%, all P < 0.05). [Ga]Ga-LNC1007 PET/CT exhibited better specificity and accuracy in diagnosing LNs (96.9% vs. 66.7% and 96.3% vs. 68.5%, all P < 0.05). However, the specificity of [Ga]Ga-LNC1007 for bone metastasis was inferior to 2-[F]FDG (15.4% vs. 88.5%, P < 0.05).
CONCLUSION
Compared with 2-[F]FDG, [Ga]Ga-LNC1007 PET/CT could detect more metastatic lesions, with higher SUVmax and TBR, in patients with mDTC. [Ga]Ga-LNC1007 had better accuracy in the diagnosis of LN and lung metastasis. Trial registration ClinicalTrials.gov NCT05515783. Registered 01 May 2022. URL of registry https://classic.
CLINICALTRIALS
gov/ct2/show/NCT05515783.
目的
本头对头比较研究旨在比较[镓]Ga-FAPI-RGD（LNC1007）和2-[氟]FDG PET/CT在评估分化型甲状腺癌转移患者（mDTC）中的性能。
方法
10例不明原因的甲状腺球蛋白血症（UHTg）患者和20例确诊为甲状腺癌转移灶的患者（DmDTC）纳入本研究。所有患者在1周内均接受了[镓]Ga-LNC1007和2-[氟]FDG PET/CT检查。最终诊断基于组织病理学结果以及实验室检查和多模态影像学特征的综合评估。
结果
在UHTg患者中，[镓]Ga-LNC1007 PET/CT检测到的转移淋巴结（LNs）（17个对15个，P = 0.317）和肺部病灶（2个对0个）比2-[氟]FDG更多。在DmDTC患者中，[镓]Ga-LNC1007 PET/CT检测到的真阳性病灶也比2-[氟]FDG更多（总数：133个对103个，LN：20个对15个，肺：18个对10个，骨：87个对73个）。与2-[氟]FDG相比，[镓]Ga-LNC1007 PET/CT在真阳性病灶中的SUVmax显著更高（总数：6.30对3.84，LN：8.28对4.82，肺：3.31对1.49，骨：5.73对3.87，所有P < 0.05）和TBR（总数：6.92对4.93，LN：6.48对4.16，肺：5.16对2.57，骨：7.22对5.41，所有P < 0.05）。具体而言，[镓]Ga-LNC1007 PET/CT在检测肺和骨转移方面的敏感性高于2-[氟]FDG（94.7%对52.6%和100%对83.9%，所有P < 0.05）。[镓]Ga-LNC1007 PET/CT在诊断LNs方面表现出更好的特异性和准确性（96.9%对66.7%和96.3%对68.5%，所有P < 0.05）。然而，[镓]Ga-LNC1007对骨转移的特异性低于2-[氟]FDG（15.4%对88.5%，P < 0.05）。
结论
与2-[氟]FDG相比，[镓]Ga-LNC1007 PET/CT在mDTC患者中能检测到更多转移病灶，具有更高的SUVmax和TBR。[镓]Ga-LNC1007在诊断LN和肺转移方面具有更好的准确性。试验注册ClinicalTrials.gov NCT05515783。于2022年5月1日注册。注册网址https://classic.
临床试验
gov/ct2/show/NCT05515783。
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