Departments of Pathology.
University of Pittsburgh School of Medicine.
J Pediatr Hematol Oncol. 2024 Nov 1;46(8):424-428. doi: 10.1097/MPH.0000000000002951. Epub 2024 Oct 14.
Most pediatric specialists, including hematologists/oncologists, surgeons, radiologists, and pathologists, are familiar with the diagnosis and management of Wilms tumor (WT). However, it may be challenging to identify the underlying conditions causing cancer predisposition, which can change the management for the patient and potentially their entire family. In this paper, we present 3 cases of clinically suspected WT associated with Beckwith-Wiedemann syndrome (BWS). We review the radiologic and histologic findings to diagnose BWS. We also discuss the implications of a BWS diagnosis on the clinical management of WT and follow-up guidelines for BWS patients.
大多数儿科专家，包括血液学家/肿瘤学家、外科医生、放射科医生和病理学家，都熟悉Wilms 瘤（WT）的诊断和治疗。然而，识别导致癌症易感性的潜在情况可能具有挑战性，这可能会改变患者及其整个家庭的治疗方案。本文报告了 3 例临床疑似与 Beckwith-Wiedemann 综合征（BWS）相关的 WT。我们回顾了诊断 BWS 的放射学和组织学发现。我们还讨论了 BWS 诊断对 WT 临床管理的影响以及 BWS 患者的随访指南。
