Raaf J H, Urmacher C, Knapper W K, Shiu M H, Cheng E W
Cancer. 1986 Jan 1;57(1):178-82. doi: 10.1002/1097-0142(19860101)57:1<178::aid-cncr2820570134>3.0.co;2-t.
Four new patients with trabecular (Merkel cell) carcinoma of the skin are described, and an additional 76 patients from the literature are reviewed. The mean age of the combined group of patients was 68; 84% were 60 years or older. Primary tumors appeared most frequently on the head and neck (44%), leg (28%), arm (16%), or buttock (9%). No primary tumor appeared on the trunk. The rate of local recurrence was 36%, regional metastatic disease, 53%; distant metastases, 28%; and death due to metastatic tumor (minimally), 25%. It appears that trabecular carcinoma of the skin is more aggressive and lethal than previously thought. The authors recommend that patients with this tumor undergo wide resection of the primary site and, in healthy patients, prophylactic regional node dissection. Both radiation therapy and chemotherapy are effective in palliating unresectable disease.
本文描述了4例新发皮肤小梁状（默克尔细胞）癌患者，并对文献中另外76例患者进行了回顾。合并后的患者组平均年龄为68岁；84%的患者年龄在60岁及以上。原发性肿瘤最常出现在头颈部（44%）、腿部（28%）、手臂（16%）或臀部（9%）。躯干未出现原发性肿瘤。局部复发率为36%，区域转移疾病为53%；远处转移为28%；因转移性肿瘤导致的死亡（最少）为25%。皮肤小梁状癌似乎比之前认为的更具侵袭性和致命性。作者建议，患有这种肿瘤的患者应进行原发部位的广泛切除，对于健康患者，应进行预防性区域淋巴结清扫。放射治疗和化疗在缓解不可切除疾病方面均有效。
