Rubenstein C, Romhilt D, Segal P, Heiss G, Chambless L E, Boyle K E, Ekelund L G, Adolph R, Sheffield L T
Circulation. 1986 Jan;73(1 Pt 2):I91-9.
The Lipid Research Clinics Prevalence Study population underwent a noninvasive evaluation to assess the odds of coronary heart disease (CHD) among individuals with various types of dyslipoproteinemia (DLP) relative to the odds for individuals free of DLP in a nonselected population. The noninvasive evaluation included the Rose questionnaire for angina, a resting electrocardiogram, and a graded treadmill exercise test. The presence of manifestations of CHD was assessed by a combination of these findings. Multiple linear regression and multiple logistic regression analyses were used to evaluate associations between CHD and DLP, with adjustments for the following covariates: age, body mass, systolic blood pressure, alcohol consumption, and cigarette use. There were no consistent associations in women or in men 30 to 49 years old. In men 50 to 69 years old, the mean high-density lipoprotein cholesterol (HDL-C) values and HDL-C/cholesterol ratio were significantly lower in the definite CHD and angina categories, compared with the negative (no evidence of CHD) group. Higher odds ratios for CHD were present in those classified as having type IIa, type IV, and hypoHDL DLPs, relative to those classified as normal by the phenotyping algorithm. These associations were consistent across the several categories of CHD manifestations, but did not reach statistical significance after adjustment for multiple testing. A statistically significant lower odds ratio for CHD was observed in men 50 to 69 classified as having hyperHDL when compared with those without DLPs. The associations between CHD and the various forms of DLP were consistent with those observed between CHD and the plasma lipid and lipoprotein-cholesterol concentrations. The Lipid Research Clinics Prevalence Study confirmed the relationship between elevated low-density lipoprotein cholesterol, decreased HDL-C, and noninvasively determined CHD in a free-living asymptomatic population of older men.
脂质研究临床患病率研究人群接受了一项非侵入性评估，以评估各类血脂蛋白异常（DLP）个体患冠心病（CHD）的几率与非特定人群中无DLP个体的几率之比。非侵入性评估包括用于评估心绞痛的罗斯问卷、静息心电图和分级平板运动试验。通过综合这些检查结果来评估CHD的表现。采用多元线性回归和多元逻辑回归分析评估CHD与DLP之间的关联，并对以下协变量进行调整：年龄、体重、收缩压、饮酒量和吸烟情况。在女性或30至49岁的男性中未发现一致的关联。在50至69岁的男性中，与阴性（无CHD证据）组相比，确诊CHD和心绞痛组的平均高密度脂蛋白胆固醇（HDL-C）值和HDL-C/胆固醇比值显著更低。与根据表型分析算法分类为正常的个体相比，分类为IIa型、IV型和低HDL DLP的个体患CHD的比值比更高。这些关联在CHD表现的几个类别中是一致的，但在多重检验调整后未达到统计学显著性。与无DLP的男性相比，50至69岁分类为高HDL的男性患CHD的比值比在统计学上显著更低。CHD与各种形式的DLP之间的关联与CHD与血浆脂质和脂蛋白胆固醇浓度之间观察到的关联一致。脂质研究临床患病率研究证实了在老年男性自由生活无症状人群中，低密度脂蛋白胆固醇升高、HDL-C降低与通过非侵入性确定的CHD之间的关系。
