蛋白质与DNA相互作用的第三条线索。
A third strand for protein-DNA interactions.
作者信息
Rusling David A, Vasquez Karen M
机构信息
School of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, Austin, TX, USA.
出版信息
Nat Chem. 2024 Nov;16(11):1748-1750. doi: 10.1038/s41557-024-01652-4.
Abstract
A method has been developed based on proximity labelling that detects the interaction of specific proteins with endogenous triplex DNA sequences formed in live cells — significantly expanding the catalogue of putative proteins that interact with these DNA structures.
摘要
一种基于邻近标记的方法已经被开发出来，该方法可检测特定蛋白质与活细胞中形成的内源性三链DNA序列的相互作用，显著扩充了与这些DNA结构相互作用的假定蛋白质目录。
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