Teng Xiaojing, Wang Xiaolei, Wang Zhiyi
Department of Clinical Laboratory, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310000, Zhejiang, China.
Department of Clinical Laboratory, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, 310008, Zhejiang, China.
Reprod Sci. 2025 Mar;32(3):825-835. doi: 10.1007/s43032-024-01720-7. Epub 2024 Oct 15.
The efficacy of Bone Marrow Mesenchymal Stem Cell-derived Exosomes (BMSCs-Exo) in addressing the complexities of Polycystic Ovary Syndrome (PCOS) has been explored in a controlled experimental study using a DHEA-induced PCOS model in 6-8-week-old female NMRI mice. This research undertook an in vivo approach with fifteen female murine subjects to investigate the potential of BMSCs-Exo in promoting vascular regeneration and alleviating the adverse effects associated with PCOS. Through a strategic intervention, the study aimed to modulate the pathophysiological markers of oxidative stress and inflammation that are hallmark features of PCOS. Remarkably, the administration of BMSCs-Exo led to decreased CD31 expression in ovarian tissues, suggesting reduced angiogenesis and endothelial activation. Moreover, a significant reduction in pro-inflammatory cytokines and oxidative stress markers was noted, aligning closely with the metrics observed in the control group. These findings illuminate a promising therapeutic avenue utilizing BMSCs-Exo to recalibrate angiogenic, inflammatory, and oxidative stress responses in PCOS. This research not only contributes to the current understanding of PCOS management but also opens new doors for innovative clinical treatments.
在一项对照实验研究中，利用6 - 8周龄雌性NMRI小鼠的脱氢表雄酮（DHEA）诱导的多囊卵巢综合征（PCOS）模型，探讨了骨髓间充质干细胞来源的外泌体（BMSCs - Exo）在应对PCOS复杂性方面的疗效。本研究采用体内实验方法，对15只雌性小鼠进行研究，以探究BMSCs - Exo在促进血管再生和减轻PCOS相关不良反应方面的潜力。通过一项策略性干预，该研究旨在调节PCOS标志性特征的氧化应激和炎症的病理生理标志物。值得注意的是，给予BMSCs - Exo导致卵巢组织中CD31表达降低，表明血管生成和内皮细胞活化减少。此外，促炎细胞因子和氧化应激标志物显著降低，与对照组观察到的指标密切一致。这些发现揭示了一条利用BMSCs - Exo重新校准PCOS血管生成、炎症和氧化应激反应的有前景的治疗途径。这项研究不仅有助于当前对PCOS管理的理解，还为创新临床治疗打开了新的大门。
