Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA.
Community Internal Medicine, Baldwin Building, 221 Fourth Ave SW, Rochester, MN, 55905, USA.
Dig Dis Sci. 2024 Nov;69(11):4048-4052. doi: 10.1007/s10620-024-08676-3. Epub 2024 Oct 15.
Data regarding histologic recurrence of EoE on PPI maintenance therapy are lacking.
Retrospective review of 101 patients with histologic PPI-responsive EoE.
52/101 (51%) patients underwent follow-up EGD with biopsies. Of the 52 patients, 29 (56%) maintained histologic remission and 23 (44%) had histologic recurrence. 21 (40%) patients maintained BID PPI, 20 (39%) tapered to QD, and 11 (21%) had discontinued PPI. Of the 21 patients on BID PPI, 7 (33%) had histologic recurrence, of which 6 (86%) were asymptomatic.
Patients on PPI therapy for EoE benefit from serial clinical, endoscopic, and histologic surveillance.
关于质子泵抑制剂(PPI)维持治疗后嗜酸性食管炎(EoE)组织学复发的数据尚缺乏。
回顾性分析 101 例组织学 PPI 应答性 EoE 患者。
101 例患者中有 52 例行内镜检查及活检随访。52 例患者中,29 例(56%)维持组织学缓解,23 例(44%)出现组织学复发。21 例(40%)患者继续使用 PPI bid,20 例(39%)逐渐减少至 PPI qd,11 例(21%)停止使用 PPI。在继续使用 PPI bid 的 21 例患者中,7 例(33%)出现组织学复发,其中 6 例(86%)无症状。
EoE 患者接受 PPI 治疗后需要进行连续的临床、内镜和组织学监测。