Pepino Carlotta, Malerba Federica, Biagioli Valentina, D'Ambrosio Talia, Zampatti Noemi, Canzoneri Francesca, Ferro Jacopo, Crocco Marco
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Child and Maternal Health, University of Genova, 16100 Genova, Italy.
Paediatric Clinic, University of Ferrara, 44124 Ferrara, Italy.
J Clin Med. 2024 Sep 30;13(19):5851. doi: 10.3390/jcm13195851.
: Celiac disease (CD) is the most common multisystemic autoimmune disorder affecting the pediatric population. However, little data is available regarding SARS-CoV-2 vaccination coverage in pediatric patients with CD. This study aims to evaluate the adherence to national recommendations for SARS-CoV-2 vaccination in children and adolescents with CD and its variation over time. : We retrospectively analyzed medical charts and electronic registry records of SARS-CoV-2 vaccination of patients aged 0-19 years diagnosed with CD in a tertiary center. The vaccination coverage was evaluated according to age groups (young children, children, and adolescents), considering the patients' eligibility for vaccination at different times. : Among the 172 patients enrolled, 44.8% received at least one dose of the SARS-CoV-2 vaccine, showing no significant differences compared to the Italian population of similar age. Vaccination coverage demonstrated a progressive reduction after an initial peak (up to 65.5% in December 2021) concomitant with a gradual extension of vaccinable eligibility and falling SARS-CoV-2 infections. Histological diagnosis and the presence of other associated autoimmune diseases were associated with higher levels of adherence to vaccination. : Adherence to the SARS-CoV-2 vaccination in young Italian children with CD was very low, while it was better in adolescents and patients with other associated autoimmune diseases. Vaccine hesitancy remains a concern, particularly among those diagnosed using the biopsy-sparing approach. Hesitancy increased during the pandemic period, suggesting the need for ongoing efforts to improve adherence to SARS-CoV-2 vaccination recommendations.
乳糜泻（CD）是影响儿童群体的最常见的多系统自身免疫性疾病。然而，关于CD患儿中SARS-CoV-2疫苗接种覆盖率的数据很少。本研究旨在评估CD儿童和青少年对SARS-CoV-2疫苗接种国家建议的依从性及其随时间的变化。
我们回顾性分析了一家三级中心诊断为CD的0至19岁患者的SARS-CoV-2疫苗接种医疗记录和电子登记记录。根据年龄组（幼儿、儿童和青少年）评估疫苗接种覆盖率，同时考虑患者在不同时间的疫苗接种资格。
在纳入的172名患者中，44.8%接受了至少一剂SARS-CoV-2疫苗，与意大利同龄人群相比无显著差异。疫苗接种覆盖率在最初的峰值（2021年12月高达65.5%）后逐渐下降，这与可接种资格的逐渐扩大和SARS-CoV-2感染率的下降同时发生。组织学诊断和其他相关自身免疫性疾病的存在与更高的疫苗接种依从性水平相关。
意大利CD幼儿对SARS-CoV-2疫苗接种的依从性非常低，而青少年和患有其他相关自身免疫性疾病的患者的依从性较好。疫苗犹豫仍然是一个问题，特别是在那些采用活检保留方法诊断的患者中。在大流行期间犹豫情绪增加，这表明需要持续努力提高对SARS-CoV-2疫苗接种建议的依从性。
