Wada Hideo, Shiraki Katsuya, Yamamoto Akitaka, Kamon Toshitaka, Masuda Jun, Ichikawa Yuhuko, Kawamura Masahide, Shimaoka Motomu, Simpo Hideto
Department of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Department of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
J Clin Med. 2024 Oct 8;13(19):5980. doi: 10.3390/jcm13195980.
: Soluble C-type lectin-like receptor -2 (sCLEC-2) has been recognized as a marker of platelet activation, and attention has been drawn to formulas combining sCLEC-2 levels with platelet count and D-dimer levels. : In this study, sCLEC-2 levels, as well as sCLEC-2/platelet count (sCLEC-2/PLT), sCLEC-2 × D-dimer (sCLEC-2xDD), and sCLEc-2xDD/PLT formulas were used to detect thrombotic diseases, including microvascular thrombosis (MVT), arterial thromboembolism (ATE), and venous thromboembolism (VTE), with the aim of evaluating the ability of the three parameters combined in these formulas to diagnose thrombotic diseases. : The plasma sCLEC-2 levels were significantly higher in patients with infectious or thrombotic diseases than in those with neither thrombosis nor infection; however, there was no significant difference among patients with infection, ATE, VTE, and MVT; the correlations among sCLEC-2, platelet count, and D-dimer level were poor. The sCLEC-2/PLT ratio was the highest in patients with MVT, and the sCLEC-2 × D-dimer value was higher in patients with MVT and VTE than in those with neither thrombosis nor infection. Although receiver operating characteristic (ROC) analysis shows the differential diagnosis of thrombotic diseases from non-thrombosis without infection, the sCLEC-2 × D-dimer/platelet count was useful for differential diagnosis among MVT and infection or non-thrombotic diseases. : sCLEC-2 is useful for the diagnosis of thrombosis, and the formulas of sCLEC-2 with platelet count or D-dimer are useful for the diagnosis of thrombosis using ROC analyses for the thrombosis group vs. the non-thrombosis group without infection.
可溶性C型凝集素样受体-2（sCLEC-2）已被公认为血小板活化的标志物，并且人们已开始关注将sCLEC-2水平与血小板计数及D-二聚体水平相结合的公式。在本研究中，使用sCLEC-2水平以及sCLEC-2/血小板计数（sCLEC-2/PLT）、sCLEC-2×D-二聚体（sCLEC-2xDD）和sCLEC-2xDD/PLT公式来检测血栓性疾病，包括微血管血栓形成（MVT）、动脉血栓栓塞（ATE）和静脉血栓栓塞（VTE），目的是评估这些公式中组合的三个参数诊断血栓性疾病的能力。感染性或血栓性疾病患者的血浆sCLEC-2水平显著高于既无血栓形成也无感染的患者；然而，感染、ATE、VTE和MVT患者之间无显著差异；sCLEC-2、血小板计数和D-二聚体水平之间的相关性较差。MVT患者的sCLEC-2/PLT比值最高，MVT和VTE患者的sCLEC-2×D-二聚体值高于既无血栓形成也无感染的患者。尽管受试者工作特征（ROC）分析显示了血栓性疾病与无感染的非血栓形成疾病的鉴别诊断，但sCLEC-2×D-二聚体/血小板计数对于MVT与感染或非血栓性疾病之间的鉴别诊断是有用的。sCLEC-2对血栓形成的诊断有用，并且sCLEC-2与血小板计数或D-二聚体的公式对于使用ROC分析血栓形成组与无感染的非血栓形成组来诊断血栓形成是有用的。
