Yamamoto Akitaka, Wada Hideo, Tomida Masaki, Ichikawa Yuhuko, Ezaki Minoru, Shiraki Katsuya, Shimaoka Motomu, Iba Toshiaki, Suzuki-Inoue Katsue, Kawamura Masahide, Shimpo Hideto
Department of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Department of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Diagnostics (Basel). 2023 Jul 6;13(13):2299. doi: 10.3390/diagnostics13132299.
The scoring systems for disseminated intravascular coagulation (DIC) criteria require several adequate cutoff values, vary, and are complicated. Accordingly, a simpler and quicker diagnostic method for DIC is needed. Under such circumstances, soluble C-type lectin-like receptor 2 (sCLEC-2) received attention as a biomarker for platelet activation.
The diagnostic usefulness of sCLEC-2 and several formulas, including sCLEC-2xD-dimer, sCLEC-2/platelet count (sCLEC-2/PLT), and sCLEC-2/PLT × D-dimer (sCLEC-2xD-dimer/PLT), were evaluated among 38 patients with DIC, 39 patients with pre-DIC and 222 patients without DIC or pre-DIC (non-DIC).
Although the plasma level of sCLEC-2 alone was not a strong biomarker for the diagnosis of DIC or pre-DIC, the sCLEC-2xD-dimer/PLT values in patients with DIC were significantly higher than those in patients without DIC, and in a receiver operating characteristic (ROC) analysis for the diagnosis of DIC, sCLEC-2xD-dimer/PLT showed the highest AUC, sensitivity, and odds ratio. This formula is useful for the diagnosis of both pre-DIC and DIC. sCLEC-2xD-dimer/PLT values were significantly higher in non-survivors than in survivors.
The sCLEC-2xD-dimer/PLT formula is simple, easy, and highly useful for the diagnosis of DIC and pre-DIC without the use of a scoring system.
弥散性血管内凝血（DIC）标准的评分系统需要几个合适的临界值，且各不相同，较为复杂。因此，需要一种更简单、快速的DIC诊断方法。在这种情况下，可溶性C型凝集素样受体2（sCLEC-2）作为血小板活化的生物标志物受到关注。
在38例DIC患者、39例DIC前期患者和222例无DIC或DIC前期（非DIC）患者中，评估了sCLEC-2以及几种公式，包括sCLEC-2×D-二聚体、sCLEC-2/血小板计数（sCLEC-2/PLT）和sCLEC-2/PLT×D-二聚体（sCLEC-2×D-二聚体/PLT）的诊断价值。
虽然单独的sCLEC-2血浆水平不是诊断DIC或DIC前期的强大生物标志物，但DIC患者的sCLEC-2×D-二聚体/PLT值显著高于非DIC患者，并且在诊断DIC的受试者工作特征（ROC）分析中，sCLEC-2×D-二聚体/PLT显示出最高的曲线下面积（AUC）、敏感性和比值比。该公式对DIC前期和DIC的诊断均有用。非幸存者的sCLEC-2×D-二聚体/PLT值显著高于幸存者。
sCLEC-2×D-二聚体/PLT公式简单、易行，在不使用评分系统的情况下对DIC和DIC前期的诊断非常有用。
