Galassi G, Nemni R
Eur Neurol. 1986;25(1):1-9. doi: 10.1159/000115979.
Electrophysiological findings in 10 patients with polyneuropathy and nonmalignant IgMk plasma cell dyscrasia are reported. The amplitude of sensory action potentials and maximum conduction velocity along the sural and median nerves are related to the structural changes found at the biopsy and to the immunologic results. Quantitative analysis of the sural nerve showed a loss of large myelinated fibers in all 8 patients, in whom the nerve could be examined. The sural action potential as well as conduction velocity were undetectable in 4 cases, diminished in 5 and normal in 1. The primary mechanism underlying nerve damage in these neuropathies is discussed. It is suggested that the IgM paraprotein may act heterogeneously on the peripheral nerve's component.
报告了10例患有多发性神经病和非恶性IgMκ浆细胞发育异常患者的电生理检查结果。感觉动作电位的幅度以及沿腓肠神经和正中神经的最大传导速度与活检时发现的结构变化以及免疫学结果相关。对腓肠神经的定量分析显示，在所有8例可检查神经的患者中，有大的有髓纤维丢失。4例患者的腓肠神经动作电位及传导速度均无法检测到，5例患者的动作电位及传导速度降低，1例患者正常。讨论了这些神经病中神经损伤的主要机制。有人提出，IgM副蛋白可能对外周神经成分起异质性作用。
