Department of Food Science and Nutrition, Kyungpook National University, 80, Daehak-ro, Buk-Ku, Daegu 41566, Republic of Korea.
Center for Food and Nutritional Genomics Research, Kyungpook National University, 80, Daehak-ro, Buk-Ku, Daegu 41566, Republic of Korea.
Int J Mol Sci. 2024 Sep 25;25(19):10302. doi: 10.3390/ijms251910302.
The significance of complex I of the electron transport chain (ETC) in the aging process is widely acknowledged; however, its specific impact on the development of sarcopenia in muscle remains poorly understood. This study elucidated the correlation between complex I inhibition and sarcopenia by conducting a comparative analysis of skeletal muscle gene expression in sarcopenia phenotypes from rats, mice, and humans. Our findings reveal a common mechanistic link across species, particularly highlighting the correlation between the suppression of complex I of ETC activity and dysregulated mitochondrial transcription and translation in sarcopenia phenotypes. Additionally, we observed macrophage dysfunction alongside abnormal metabolic processes within skeletal muscle tissues across all species, implicating their pathogenic role in the onset of sarcopenia. These discoveries underscore the importance of understanding the shared mechanisms associated with complex I of ETC in sarcopenia development. The identified correlations provide valuable insights into potential targets for therapeutic interventions aimed at mitigating the impact of sarcopenia, a condition with substantial implications for aging populations.
电子传递链（ETC）复合体 I 在衰老过程中的重要性已被广泛认可；然而，其对肌肉中进行性肌肉减少症发展的具体影响仍知之甚少。本研究通过对大鼠、小鼠和人类进行性肌肉减少症表型的骨骼肌基因表达进行比较分析，阐明了复合体 I 抑制与进行性肌肉减少症之间的相关性。我们的研究结果揭示了物种间存在共同的机制联系，特别是突出了 ETC 活性复合体 I 抑制与进行性肌肉减少症表型中线粒体转录和翻译失调之间的相关性。此外，我们观察到所有物种的骨骼肌组织中存在巨噬细胞功能障碍以及异常代谢过程，表明它们在进行性肌肉减少症的发病机制中具有致病作用。这些发现强调了理解与 ETC 复合体 I 相关的共同机制在进行性肌肉减少症发展中的重要性。所确定的相关性为治疗干预的潜在靶点提供了有价值的见解，这些靶点旨在减轻进行性肌肉减少症的影响，这种情况对老年人口具有重要意义。
