Touchon J, Valmier J, Baldy-Moulinier M, Cadilhac J
Eur Neurol. 1986;25(1):43-52. doi: 10.1159/000115986.
Regional cerebral blood flow (rCBF) was investigated during interictal state by 133Xenon intravenous clearance technique in two groups of epileptic patients: group I (n = 28) having partial complex seizures (temporal lobe epilepsy); group II (n = 14) having generalized seizures (primary generalized epilepsy). Mean hemispheric CBF was decreased in group I and unchanged in group II compared to normal controls. Modifications in rCBF pattern were observed in group I but not in group II. A marked hypoperfusion of one temporal region was found in patients from group I showing a unilateral and fixed epileptic focus. Hypoperfusion of other cerebral areas at a distance from the epileptic focus was greater for patients with a left epileptic focus than for those with a right epileptic focus. Patients with the same severity of disease and bilateral and variable foci had no significant modification of mean hemispheric CBF and rCBF distribution. These observations indicate that interictal investigations of rCBF may be of interest for a differential classification of epilepsy.
采用氙 - 133静脉清除技术，在发作间期对两组癫痫患者的局部脑血流量（rCBF）进行了研究：第一组（n = 28）为部分性复杂性发作（颞叶癫痫）；第二组（n = 14）为全身性发作（原发性全身性癫痫）。与正常对照组相比，第一组平均半球脑血流量降低，第二组则无变化。第一组观察到rCBF模式有改变，而第二组未观察到。在显示单侧固定癫痫灶的第一组患者中，发现一个颞叶区域有明显灌注不足。左癫痫灶患者距癫痫灶较远的其他脑区灌注不足比右癫痫灶患者更严重。疾病严重程度相同且有双侧可变病灶的患者，平均半球脑血流量和rCBF分布无明显改变。这些观察结果表明，发作间期rCBF检查可能对癫痫的鉴别分类有意义。
