Centro de Investigación Multidisciplinario en Salud, Departamento de Ciencias Biomédicas, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá 45425, Mexico.
Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Int J Mol Sci. 2024 Sep 29;25(19):10491. doi: 10.3390/ijms251910491.
Chronic migraines have been described chiefly only from a clinical perspective. However, searching for reliable molecular markers has allowed for the discovery of the expression of different genes mainly associated with inflammation, neuro-vascularization, and pain-related pathways. The interest in microRNAs (miRs) that can regulate the expression of these genes has gained significant relevance since multiple miRs could play a key role in regulating these events. In this study, miRs were searched in samples from patients with chronic migraine, and the inclusion criteria were carefully reviewed. Different bioinformatic tools, such as miRbase, targetscan, miRPath, tissue atlas, and miR2Disease, were used to analyze the samples. Our findings revealed that some of the miRs were expressed more (miR-197, miR-101, miR-92a, miR-375, and miR-146b) and less (miR-133a/b, miR-134, miR-195, and miR-340) than others. We concluded that, during chronic migraine, common pathways, such as inflammation, vascularization, neurodevelopment, nociceptive pain, and pharmacological resistance, were associated with this disease.
慢性偏头痛主要仅从临床角度进行描述。然而，寻找可靠的分子标志物使得能够发现主要与炎症、神经血管生成和与疼痛相关的途径相关的不同基因的表达。由于多个 microRNAs (miRs) 可以调节这些基因的表达，因此对 microRNAs 的研究具有重要意义，因为这些 microRNAs 可能在调节这些事件中发挥关键作用。在这项研究中，从慢性偏头痛患者的样本中搜索了 miRs，并仔细审查了纳入标准。使用了不同的生物信息学工具，如 miRbase、targetscan、miRPath、组织图谱和 miR2Disease，来分析样本。我们的研究结果表明，一些 miRs 的表达量更高（miR-197、miR-101、miR-92a、miR-375 和 miR-146b）或更低（miR-133a/b、miR-134、miR-195 和 miR-340）。我们得出结论，在慢性偏头痛期间，炎症、血管生成、神经发育、伤害性疼痛和药物耐药性等常见途径与该疾病相关。
