Institute of Medical Science Technology, Universiti Kuala Lumpur (UniKL), A1-1, Jalan TKS 1, Taman Kajang Sentral, Kajang 43000, Selangor, Malaysia.
Royal College of Medicine Perak, Universiti Kuala Lumpur (UniKL), No. 3, Jalan Greentown, Ipoh 30450, Perak, Malaysia.
Int J Mol Sci. 2024 Oct 8;25(19):10785. doi: 10.3390/ijms251910785.
Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes that affects a significant proportion of diabetic patients worldwide. Although the pathogenesis of DPN involves axonal atrophy and demyelination, the exact mechanisms remain elusive. Current research has predominantly focused on neuronal damage, overlooking the potential contributions of Schwann cells, which are the predominant glial cells in the peripheral nervous system. Schwann cells play a critical role in neurodevelopment, neurophysiology, and nerve regeneration. This review highlights the emerging understanding of the involvement of Schwann cells in DPN pathogenesis. This review explores the potential role of Schwann cell plasticity as an underlying cellular and molecular mechanism in the development of DPN. Understanding the interplay between Schwann cell plasticity and diabetes could reveal novel strategies for the treatment and management of DPN.
糖尿病周围神经病变（DPN）是一种普遍的糖尿病并发症，影响着全球很大一部分糖尿病患者。尽管 DPN 的发病机制涉及轴突萎缩和脱髓鞘，但确切的机制仍不清楚。目前的研究主要集中在神经元损伤上，而忽略了 Schwann 细胞的潜在贡献，Schwann 细胞是周围神经系统中主要的神经胶质细胞。Schwann 细胞在神经发育、神经生理学和神经再生中起着关键作用。这篇综述强调了 Schwann 细胞在 DPN 发病机制中的作用的新认识。本综述探讨了 Schwann 细胞可塑性作为 DPN 发展中潜在的细胞和分子机制的作用。了解 Schwann 细胞可塑性与糖尿病之间的相互作用可能为 DPN 的治疗和管理提供新的策略。
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