Singer M V, Niebel W, Kniesburges S, Hoffmeister D, Goebell H
Gastroenterology. 1986 Feb;90(2):355-61. doi: 10.1016/0016-5085(86)90932-7.
In two sets of dogs with gastric and pancreatic fistulas, we studied the effect of atropine on the pancreatic secretory response to intravenous secretin before and after cutting the extrinsic nerves of the pancreas, i.e., celiac and superior mesenteric ganglionectomy alone or truncal vagotomy plus celiac and superior mesenteric ganglionectomy. Neither truncal vagotomy alone nor ganglionectomy alone, nor the two together, altered the incremental bicarbonate response to secretin. Irrespective of the degree of integrity of the extrinsic vagal and splanchnic innervation of the pancreas, intravenous atropine (14 nmol/kg X h) significantly (p less than 0.05) depressed the incremental bicarbonate responses to the two lowest (5.2 and 10.3 pmol/kg X h) doses of secretin by 85% and 61%, respectively, but had no significant effect on responses to high doses. We conclude that the pancreatic bicarbonate response to secretin, and the action of atropine on that response, are independent of an intact extrinsic innervation of the gland. The observation of the persistent inhibitory action of atropine after extrinsic denervation of the pancreas is compatible with the hypothesis that endogenous cholinergic activity augments the pancreatic bicarbonate response to secretin.
在两组患有胃瘘和胰瘘的狗中，我们研究了在切断胰腺的外在神经（即单独进行腹腔神经节和肠系膜上神经节切除术，或迷走神经干切断术加腹腔神经节和肠系膜上神经节切除术）前后，阿托品对静脉注射促胰液素引起的胰腺分泌反应的影响。单独进行迷走神经干切断术、单独进行神经节切除术，或两者一起进行，均未改变对促胰液素的碳酸氢盐增量反应。无论胰腺的外在迷走神经和内脏神经的完整程度如何，静脉注射阿托品（14 nmol/kg·h）均显著（p<0.05）降低了对两种最低剂量（5.2和10.3 pmol/kg·h）促胰液素的碳酸氢盐增量反应，分别降低了85%和61%，但对高剂量反应无显著影响。我们得出结论，胰腺对促胰液素的碳酸氢盐反应以及阿托品对该反应的作用与腺体完整的外在神经支配无关。胰腺外在去神经支配后阿托品持续具有抑制作用的观察结果与内源性胆碱能活性增强胰腺对促胰液素的碳酸氢盐反应这一假设相符。
