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某物种遗传资源叶片提取物对HT22细胞和BV2细胞的神经保护及抗神经炎症作用。

Effects of Leaf Extracts from Genetic Resource of spp. on Neuroprotection and Anti-Neuroinflammation in HT22 and in BV2 Cells.

作者信息

Dong Linsha, Choi Bo-Ram, Jeong Hyo Bong, Lee Hwan, Liu Zhiming, Yoon Dahye, Lee Hye Eun, Lee Dong-Sung, Lee Dae Young

机构信息

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.

Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 27709, Republic of Korea.

出版信息

Plants (Basel). 2024 Oct 8;13(19):2820. doi: 10.3390/plants13192820.

DOI:10.3390/plants13192820
PMID:39409690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11478504/
Abstract

To develop functional varieties of spp. leaves, 40 genetic resources were collected and extracted with 30% aqueous-fermented ethanol. We investigated the protective effects of extracts from 40 genetic resources of spp. on glutamate-induced HT22 and LPS-induced BV2 cells. The results showed that the five extracts exhibited cell-protective activities. We also investigated the anti-inflammatory effects of these five extracts on LPS-induced BV2 cell neuroinflammation and found that 23OM18 exhibited superior anti-inflammatory effects. We further investigated the protective activity and anti-inflammatory mechanisms of 23OM18 in these two cell models. In addition, the profiles of 16 metabolites were compared between the representative accessions and among the five genetic resources using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). The results showed that 23OM18 protected HT22 cells by inhibiting reactive oxygen species generation and regulating the MAPK-JNK signaling pathway, thereby reducing LPS-induced BV2 cell neuroinflammation by regulating the NF-κB and MAPK signaling pathways. Based on these results, 23OM18 has the potential to be developed as a functional food for the treatment of neurodegenerative diseases.

摘要

为了培育某物种叶片的功能性品种，收集了40份遗传资源，并用30%的发酵乙醇水溶液进行提取。我们研究了某物种40份遗传资源的提取物对谷氨酸诱导的HT22细胞和脂多糖诱导的BV2细胞的保护作用。结果表明，有五种提取物表现出细胞保护活性。我们还研究了这五种提取物对脂多糖诱导的BV2细胞神经炎症的抗炎作用，发现23OM18表现出卓越的抗炎效果。我们进一步研究了23OM18在这两种细胞模型中的保护活性和抗炎机制。此外，使用超高效液相色谱四极杆飞行时间质谱（UHPLC-QTOF-MS）比较了代表性种质之间以及五种遗传资源之间16种代谢物的图谱。结果表明，23OM18通过抑制活性氧的产生和调节MAPK-JNK信号通路来保护HT22细胞，从而通过调节NF-κB和MAPK信号通路减轻脂多糖诱导的BV2细胞神经炎症。基于这些结果，23OM18有潜力被开发成一种用于治疗神经退行性疾病的功能性食品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/462e51ad8548/plants-13-02820-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/344bd7ad913c/plants-13-02820-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/b6de06a85792/plants-13-02820-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/1c52bcc4ad45/plants-13-02820-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/0097cef8d191/plants-13-02820-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/31f3573a81e8/plants-13-02820-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/e06f5f686f07/plants-13-02820-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/494e802d2734/plants-13-02820-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/462e51ad8548/plants-13-02820-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/344bd7ad913c/plants-13-02820-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/b6de06a85792/plants-13-02820-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/1c52bcc4ad45/plants-13-02820-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/0097cef8d191/plants-13-02820-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/31f3573a81e8/plants-13-02820-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/e06f5f686f07/plants-13-02820-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/494e802d2734/plants-13-02820-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b0/11478504/462e51ad8548/plants-13-02820-g008.jpg

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