Ghebremedhin Anghesom, Athavale Dipti, Zhang Yanting, Yao Xiaodan, Balch Curt, Song Shumei
Coriell Institute for Medical Research, 403 Haddon Ave., Camden, NJ 08103, USA.
Department Biomedical Sciences, Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ 08103, USA.
Cancers (Basel). 2024 Oct 8;16(19):3410. doi: 10.3390/cancers16193410.
Within the tumor microenvironment, myeloid cells constitute a dynamic immune population characterized by a heterogeneous phenotype and diverse functional activities. In this review, we consider recent literature shedding light on the increasingly complex biology of M2-like immunosuppressive tumor-associated macrophages (TAMs), including their contribution to tumor cell invasion and metastasis, stromal remodeling (fibrosis and matrix degradation), and immune suppressive functions, in the tumor microenvironment (TME). This review also delves into the intricate signaling mechanisms underlying the polarization of diverse macrophage phenotypes, and their plasticity. We also review the development of promising therapeutic approaches to target these populations in cancers. The expanding knowledge of distinct subsets of immunosuppressive TAMs, and their contributions to tumorigenesis and metastasis, has sparked significant interest among researchers regarding the therapeutic potential of TAM depletion or phenotypic modulation.
在肿瘤微环境中，髓系细胞构成了一个动态的免疫群体，其特征是具有异质性表型和多样的功能活性。在本综述中，我们探讨了近期的文献，这些文献揭示了M2样免疫抑制性肿瘤相关巨噬细胞（TAM）日益复杂的生物学特性，包括它们在肿瘤微环境（TME）中对肿瘤细胞侵袭和转移、基质重塑（纤维化和基质降解）以及免疫抑制功能的贡献。本综述还深入研究了不同巨噬细胞表型极化背后的复杂信号机制及其可塑性。我们还回顾了针对癌症中这些细胞群体的有前景的治疗方法的进展。对免疫抑制性TAM不同亚群的不断扩展的认识，以及它们对肿瘤发生和转移的贡献，引发了研究人员对TAM耗竭或表型调节治疗潜力的浓厚兴趣。
