Department of Stomatology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 43400, China.
Experimental and Practical Teaching Center, Hubei College of Chinese Medicine, Jingzhou, Hubei 434000, China.
Biomed Pharmacother. 2024 Nov;180:117458. doi: 10.1016/j.biopha.2024.117458. Epub 2024 Oct 15.
Oral cancers are a significant global health concern, with a high incidence of treatment failure primarily due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression, playing pivotal roles in various cellular processes, including tumor progression and response to therapy. This review explores the multifaceted roles of lncRNAs in the development of drug resistance in oral cancers. We highlight the mechanisms by which lncRNAs modulate drug efflux, apoptosis, epithelial-mesenchymal transition (EMT), and other pathways associated with chemoresistance. Key lncRNAs implicated in resistance to commonly used chemotherapeutic agents in oral cancers are discussed, along with their potential as therapeutic targets. Understanding the involvement of lncRNAs in drug resistance mechanisms offers promising avenues for overcoming treatment barriers and improving patient outcomes. This review underscores the need for further research to elucidate the precise roles of lncRNAs in oral cancer resistance and their translation into clinical interventions.
口腔癌是一个全球性的重大健康问题，其治疗失败的发生率很高，主要是由于耐药性的发展。长链非编码 RNA（lncRNA）已成为基因表达的关键调控因子，在包括肿瘤进展和对治疗的反应在内的各种细胞过程中发挥关键作用。本综述探讨了 lncRNA 在口腔癌耐药性发展中的多种作用。我们强调了 lncRNA 调节药物外排、细胞凋亡、上皮-间充质转化（EMT）和其他与化疗耐药性相关途径的机制。讨论了与口腔癌中常用化疗药物耐药性相关的关键 lncRNA，并探讨了它们作为治疗靶点的潜力。了解 lncRNA 在耐药性机制中的参与为克服治疗障碍和改善患者预后提供了有前途的途径。本综述强调了进一步研究阐明 lncRNA 在口腔癌耐药性中的确切作用及其转化为临床干预措施的必要性。
