Kretzler Madison E, Huang Sherry S, Sun Jessie E P, Bittencourt Leonardo K, Chen Yong, Griswold Mark A, Boyacioglu Rasim
Dept. of Radiology, Case Western Reserve University, 11100 Euclid Ave / Bolwell B115, Cleveland, OH, 44106, USA.
Dept. of Radiology, University Hospitals, Cleveland, OH, USA.
MAGMA. 2025 Feb;38(1):85-95. doi: 10.1007/s10334-024-01209-z. Epub 2024 Oct 16.
Standard quantitative abdominal MRI techniques are time consuming, require breath-holds, and are susceptible to patient motion artifacts. Magnetic resonance fingerprinting (MRF) is naturally multi-parametric and quantifies multiple tissue properties, including T and T. This work includes T* and off-resonance mapping into a free-breathing MRF framework utilizing a pilot tone navigator. The new acquisition and reconstruction are compared to current clinical standards. Prospective. Ten volunteers. 3 T scanner, Quadratic-RF MRF, Balanced SSFP, Inversion recovery spin-echo, LiverLab. MRI ROIs were evaluated in the liver, spleen, pancreas, kidney (cortex and medulla), and paravertebral muscle by two abdominal imaging investigators for ten healthy adult volunteers for clinical standard, breath-Hold (BH) qRF-MRF, and free-breathing qRF-MRF with pilot-tone (PT) acquisitions. Bland-Altman analysis as well as Student's T tests were used to evaluate and compare the respective ROI analyses. Quantitative values between breath-Hold (BH) and free-breathing qRF-MRF with pilot-tone (PT) results show good agreement with clinical standard T1 and T2 quantitative mapping, and Dixon q-VIBE (acquired using the Siemens LiverLAB). In this work, we show free-breathing abdominal MRF (T, T) with T* results that are quantitatively comparable to current breath-hold MRF and clinical techniques.
标准的定量腹部MRI技术耗时较长，需要屏气，且易受患者运动伪影的影响。磁共振指纹识别（MRF）本质上是多参数的，可量化多种组织特性，包括T1和T2。这项工作将T和失谐映射纳入一个利用导频音导航器的自由呼吸MRF框架。将新的采集和重建方法与当前临床标准进行比较。前瞻性研究。10名志愿者。3T扫描仪、二次射频MRF、平衡稳态自由进动序列、反转恢复自旋回波序列、LiverLab软件。由两名腹部影像研究人员对10名健康成年志愿者的肝脏、脾脏、胰腺、肾脏（皮质和髓质）以及椎旁肌的MRI感兴趣区（ROI）进行评估，分别采用临床标准、屏气（BH）二次射频MRF以及带有导频音（PT）采集的自由呼吸二次射频MRF。采用Bland-Altman分析以及学生t检验来评估和比较各自的ROI分析。屏气（BH）和带有导频音（PT）的自由呼吸二次射频MRF之间的定量值与临床标准T1和T2定量映射以及Dixon定量容积内插屏气检查（使用西门子LiverLAB软件采集）结果显示出良好的一致性。在这项工作中，我们展示了自由呼吸腹部MRF（T1、T2）以及T结果，其在定量方面可与当前屏气MRF和临床技术相媲美。
