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天然黄酮柚皮素还原氧化石墨烯纳米片对非酒精性脂肪性肝病可能的保护作用

Possible protective effect of natural flavanone naringenin-reduced graphene oxide nanosheets on nonalcoholic fatty liver disease.

作者信息

Abdelmoneim Doaa, Eldomany Ehab B, El-Adl Mohamed, Farghali Ahmed, El-Sayed Gehad, El-Sherbini El Said

机构信息

Biochemistry and Chemistry of Nutrition Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.

Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, 62511, Egypt.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):4071-4086. doi: 10.1007/s00210-024-03495-9. Epub 2024 Oct 16.

DOI:10.1007/s00210-024-03495-9
PMID:39414698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11978702/
Abstract

Utilizing naringenin as a safe, natural compound for reducing graphene oxide and to determine whether Nar-RGO more effectively mitigates the harmful effects of HFFD-induced NAFLD compared to crude naringenin. Using a straightforward experimental setup, we utilize the bioactive flavonoid naringenin (NAR) as the reducing agent to synthesize naringenin-reduced graphene oxide nanosheets (Nar-RGO). Naringenin loading on graphene oxide was validated using electroscopic methods (SEM and TEM) and zeta potential measurements. Utilization of reduced graphene oxide for naringenin encapsulation resulted in a significant improvement in hepatic steatosis, insulin resistance, oxidative stress, and signs of inflammation in HFFD-induced NAFLD compared to crude naringenin. This study demonstrates that Nar-RGO exhibits significantly greater efficacy compared to free naringenin. Therefore, it can be used as a promising medicine in counteracting high-fat-fructose diet (HFFD)-induced NAFLD.

摘要

利用柚皮素作为一种安全的天然化合物来还原氧化石墨烯，并确定与粗柚皮素相比，Nar-RGO是否能更有效地减轻高脂高糖饮食（HFFD）诱导的非酒精性脂肪性肝病（NAFLD）的有害影响。通过一个简单的实验设置，我们利用生物活性类黄酮柚皮素（NAR）作为还原剂来合成柚皮素还原的氧化石墨烯纳米片（Nar-RGO）。使用电子显微镜方法（扫描电子显微镜和透射电子显微镜）和zeta电位测量来验证氧化石墨烯上柚皮素的负载情况。与粗柚皮素相比，利用还原氧化石墨烯包裹柚皮素可显著改善HFFD诱导的NAFLD中的肝脂肪变性、胰岛素抵抗、氧化应激和炎症迹象。这项研究表明，与游离柚皮素相比，Nar-RGO表现出显著更高的疗效。因此，它可以作为一种有前景的药物来对抗高脂高糖饮食（HFFD）诱导的NAFLD。

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