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撤回:褪黑素对脂肪肝疾病的影响:NR4A1/DNA-Pkcs/P53通路、线粒体分裂和线粒体自噬的作用

RETRACTION: Effects of Melatonin on Fatty Liver Disease: The Role of NR4A1/DNA-Pkcs/P53 Pathway, Mitochondrial Fission, and Mitophagy.

出版信息

J Pineal Res. 2024 Oct;76(7):e70001. doi: 10.1111/jpi.70001.

DOI:10.1111/jpi.70001
PMID:39415080
Abstract

H. Zhou, W. Du, Y. Li, C. Shi, N. Hu, S. Ma, W. Wang, and J. Ren, "Effects of Melatonin on Fatty Liver Disease: The Role of NR4A1/DNA-Pkcs/P53 Pathway, Mitochondrial Fission, and Mitophagy," Journal of Pineal Research 64, no. 1 (2018): e12450, https://doi.org/10.1111/jpi.12450. The above article, published online on 05 October 2017, in Wiley Online Library (wileyonlinelibrary.com) and its correction (https://doi.org/10.1111/jpi.12946) have been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into additional concerns raised by a third party regarding the scientific integrity of the generation of DNA-PKcsfl/fl mouse model and the reliability of the data presented in Figure 4 A and J, Figure 5E-G and Figure 7A and E. The original raw data was not available upon request from the authors. The senior corresponding author's institute stated that the study was not conducted at their university. Given the extent of the identified issues, the editors have lost confidence in the data presented and the article's conclusions can no longer be considered reliable. The first author disagrees with the retraction, and all other authors remained unresponsive.

摘要

周H、杜W、李Y、施C、胡N、马S、王W、任J,《褪黑素对脂肪肝疾病的影响:NR4A1/DNA-Pkcs/P53信号通路、线粒体分裂和线粒体自噬的作用》,《松果体研究杂志》第64卷,第1期(2018年):e12450,https://doi.org/10.1111/jpi.12450 。上述文章于2017年10月5日在线发表于威利在线图书馆(wileyonlinelibrary.com),其勘误(https://doi.org/10.1111/jpi.12946)已根据期刊主编詹卢卡·托西尼与约翰·威利父子有限公司的协议撤回。在第三方对DNA-PKcsfl/fl小鼠模型构建的科学完整性以及图4 A和J、图5E - G以及图7A和E中呈现的数据的可靠性提出更多担忧后,经调查达成了撤回协议。应要求,作者无法提供原始原始数据。资深通讯作者所在机构表示该研究并非在其大学进行。鉴于已发现问题的严重程度,编辑们对所呈现的数据失去了信心,文章的结论也不再被认为可靠。第一作者不同意撤回,其他所有作者均未回应。

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