Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Cardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
BMC Cardiovasc Disord. 2024 Oct 17;24(1):566. doi: 10.1186/s12872-024-04235-w.
The characteristics of electrocardiogram (ECG) abnormalities related to cardiac channelopathies potentially linked to sudden cardiac death (SCD) are not widely recognized in Iran. We examined the prevalence of such ECG patterns and their related factors among adult residents of Tehran, Iran.
The clinical characteristics and 12-lead ECGs of Tehran Cohort Study participants were examined. Long QT intervals, short QT intervals, Brugada syndrome (BrS) patterns, and early repolarization (ER) were evaluated using computer-based assessment software validated by cardiologists. Logistic regression models were employed to identify the factors associated with the prevalence of different ECG patterns.
Out of 7678 available ECGs, 7350 were included in this analysis. Long QT interval, ER pattern, BrS patterns, and short QT interval were found in 3.08%, 1.43%, 0.31%, and 0.03% of participants, respectively. The prevalence of long QT interval increased with age, opium consumption, and presence of hypertension. Younger age, lower body mass index (BMI), alcohol use and male sex were independently linked to an elevated prevalence of ER pattern. Most individuals with BrS patterns were men (95%) and had lower BMI, high- and low-density lipoprotein, and total cholesterol compared to those without the BrS pattern. At a mean follow-up of 30.2 ± 5.5 months, all-cause mortality in the group exhibiting abnormal ECG patterns (6.3%) was approximately twice as high as that in the group without such patterns (2.96%).
Abnormal ECG patterns corresponding to channelopathies were relatively rare among adult residents of the Tehran population, and their prevalence was influenced by various factors.
Not applicable.
与心脏通道病相关的心电图（ECG）异常特征在伊朗并不广泛被认识到，这些特征可能与心脏性猝死（SCD）有关。我们研究了伊朗德黑兰成年居民中此类心电图模式及其相关因素的流行情况。
检查了德黑兰队列研究参与者的临床特征和 12 导联心电图。使用经心脏病专家验证的基于计算机的评估软件评估长 QT 间期、短 QT 间期、Brugada 综合征（BrS）模式和早期复极（ER）。采用逻辑回归模型确定与不同心电图模式流行相关的因素。
在 7678 份可获得的心电图中，有 7350 份纳入本分析。3.08%、1.43%、0.31%和 0.03%的参与者分别存在长 QT 间期、ER 模式、BrS 模式和短 QT 间期。长 QT 间期的患病率随年龄、鸦片类药物使用和高血压的存在而增加。较年轻、较低的体重指数（BMI）、饮酒和男性与 ER 模式的高患病率独立相关。BrS 模式的大多数患者为男性（95%），且与无 BrS 模式的患者相比，其 BMI、高低密度脂蛋白和总胆固醇较低。在平均 30.2±5.5 个月的随访期间，异常心电图模式组（6.3%）的全因死亡率约为无异常心电图模式组（2.96%）的两倍。
在德黑兰人群的成年居民中，与通道病相关的异常心电图模式相对较少，其流行情况受多种因素影响。
不适用。
