甘油三酯-葡萄糖指数与酒精使用障碍危重症患者的全因死亡率相关：一项回顾性队列研究。

Triglyceride-glucose index is associated with all-cause mortality in critically ill patients with alcohol use disorder: a retrospective cohort study.

机构信息

Department of Pharmacy, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, 325000, Zhejiang, China.

Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

出版信息

J Health Popul Nutr. 2024 Oct 16;43(1):161. doi: 10.1186/s41043-024-00662-9.

BACKGROUND

The relationship between Triglyceride-glucose (TyG) index and clinical outcomes in patients with alcohol use disorder (AUD) is unclear. The aim of this study was to evaluate the association between TyG index and all-cause mortality in critically ill patients with AUD.

METHODS

We used data from the multi-parameter intelligent monitoring in intensive care IV (MIMIC-IV) database. The patients were equally divided into quartiles. Kaplan-Meier curves were used for survival analysis. The primary endpoint of the study was 28-day mortality, followed by 1-year mortality. We used Cox proportional hazard models to assess the relationship between TyG index and all-cause mortality at different endpoints.

RESULTS

A total of 537 AUD patients were included. Using TyG value as a continuous variable (HR 1.460, 95% CI 1.121-1.903, p = 0.005) and categorical variable (HR 1.447-3.477 from Q2 to Q4, with Q1 as reference), elevated TyG value was significantly associated with increased 28-day mortality. TyG was positively associated with 1-year mortality in AUD patients with an HR of 1.295 (95% CI 1.011-1.659, p = 0.041).

CONCLUSION

TyG index is positively associated with different clinical outcomes of critically ill AUD patients.

背景

甘油三酯-葡萄糖（TyG）指数与酒精使用障碍（AUD）患者的临床结局之间的关系尚不清楚。本研究旨在评估 TyG 指数与危重症 AUD 患者全因死亡率之间的关系。

方法

我们使用了多参数智能监测重症监护 IV（MIMIC-IV）数据库的数据。患者被平均分为四组。使用 Kaplan-Meier 曲线进行生存分析。本研究的主要终点是 28 天死亡率，其次是 1 年死亡率。我们使用 Cox 比例风险模型评估 TyG 指数与不同终点全因死亡率之间的关系。

结果

共纳入 537 例 AUD 患者。将 TyG 值作为连续变量（HR 1.460，95%CI 1.121-1.903，p=0.005）和分类变量（Q2 到 Q4 的 HR 为 1.447-3.477，以 Q1 为参考）使用时，升高的 TyG 值与 28 天死亡率升高显著相关。TyG 与 AUD 患者的 1 年死亡率呈正相关，HR 为 1.295（95%CI 1.011-1.659，p=0.041）。