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卡泊三醇/倍他米松二丙酸酯泡沫固定剂量复方制剂在日常临床实践中治疗轻度至中度银屑病的临床经验汇总

Fixed-dose combination of calcipotriene/betamethasone dipropionate foam for the management of mild-to-moderate psoriasis in daily clinical practice: a collection of clinical experiences.

作者信息

Campanati Anna, Esposito Maria, Caldarola Giacomo, Cacciapuoti Sara, Fabbrocini Gabriella

机构信息

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

Dermatology - Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

出版信息

Drugs Context. 2024 Oct 9;13. doi: 10.7573/dic.2023-11-5. eCollection 2024.

DOI:10.7573/dic.2023-11-5
PMID:39416771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11482089/
Abstract

A fixed-dose combination of calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) aerosol foam (Enstilar, LEO Pharma) is the only topical therapy approved for the acute (reactive) and proactive management of psoriasis. Although treatment with Cal/BD foam has been characterized in a clinical context, further evidence is needed to determine its optimal use in clinical practice. A group of experts discussed the value of the Cal/BD foam as a topical treatment for mild-to-moderate psoriasis in combination with systemic treatments. The reported experiences support effectiveness of the Cal/BD foam in daily clinical practice, with an improvement in patient quality of life.

摘要

钙泊三醇0.005%/二丙酸倍他米松0.064%(Cal/BD)气雾剂泡沫(恩斯梯拉,LEO制药公司)的固定剂量组合是唯一被批准用于银屑病急性(反应性)和预防性治疗的局部疗法。尽管Cal/BD泡沫治疗已在临床背景下得到描述,但仍需要进一步的证据来确定其在临床实践中的最佳使用方法。一组专家讨论了Cal/BD泡沫作为轻度至中度银屑病局部治疗联合全身治疗的价值。报告的经验支持Cal/BD泡沫在日常临床实践中的有效性,可改善患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/27b5025ddace/DIC-2023-11-5_CAMPANATI-Figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/a7296d1115a1/DIC-2023-11-5_CAMPANATI-Figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/d85e992af5ea/DIC-2023-11-5_CAMPANATI-Figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/04f43e43380b/DIC-2023-11-5_CAMPANATI-Figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/8443bc4dffa9/DIC-2023-11-5_CAMPANATI-Figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/27b5025ddace/DIC-2023-11-5_CAMPANATI-Figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/a7296d1115a1/DIC-2023-11-5_CAMPANATI-Figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/d85e992af5ea/DIC-2023-11-5_CAMPANATI-Figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/04f43e43380b/DIC-2023-11-5_CAMPANATI-Figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/8443bc4dffa9/DIC-2023-11-5_CAMPANATI-Figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea2/11482089/27b5025ddace/DIC-2023-11-5_CAMPANATI-Figure5.jpg

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本文引用的文献

1
Novel concepts in psoriasis: histopathology and markers related to modern treatment approaches.银屑病的新概念:与现代治疗方法相关的组织病理学和标志物。
Rom J Morphol Embryol. 2021 Oct-Dec;62(4):897-906. doi: 10.47162/RJME.62.4.02.
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Long-term proactive management of psoriasis with calcipotriol and betamethasone dipropionate foam: an Italian consensus through a combined nominal group technique and Delphi approach.采用卡泊三醇和倍他米松二丙酸酯泡沫进行银屑病的长期主动治疗:通过联合名义群体技术和德尔菲法达成的意大利共识。
Int J Dermatol. 2022 Dec;61(12):1543-1551. doi: 10.1111/ijd.16192. Epub 2022 May 24.
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Efficacy of calcipotriol plus betamethasone dipropionate foam on psoriatic skin lesions beyond human eyes: An observational study.
卡泊三醇倍他米松二丙酸酯泡沫剂对人眼难以察觉的银屑病皮损的疗效:一项观察性研究。
Health Sci Rep. 2022 Apr 26;5(3):e597. doi: 10.1002/hsr2.597. eCollection 2022 May.
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Proactive vs. reactive psoriasis therapy: a long-term evaluation with dermoscopic and confocal microscopy assessment.主动与被动治疗银屑病:一种基于皮肤镜和共聚焦显微镜评估的长期评估。
Eur Rev Med Pharmacol Sci. 2022 Mar;26(6):2018-2024. doi: 10.26355/eurrev_202203_28350.
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Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment.卡泊三醇/倍他米松二丙酸酯不同剂型治疗银屑病的疗效与安全性:凝胶剂、泡沫剂和软膏剂
J Clin Med. 2021 Nov 28;10(23):5589. doi: 10.3390/jcm10235589.
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Systematic literature review of long-term efficacy data for topical psoriasis treatments.系统性文献回顾:局部治疗银屑病的长期疗效数据。
J Dermatolog Treat. 2022 Jun;33(4):2118-2128. doi: 10.1080/09546634.2021.1925211. Epub 2021 Jun 1.
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Dermatol Ther (Heidelb). 2020 Oct;10(5):1111-1120. doi: 10.1007/s13555-020-00419-2. Epub 2020 Aug 12.