环状信使核糖核酸：一种新型治疗剂。
Circular mRNA: A novel therapeutic agent.
作者信息
Wang Xiaoxue, Dong Jian, Lu Yuan
机构信息
Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Key Laboratory of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
出版信息
Biotechnol Notes. 2023 Sep 24;4:58-63. doi: 10.1016/j.biotno.2023.09.001. eCollection 2023.
Circular mRNA (circmRNA) is a covalent closed loop formed by reverse splicing of the 3' end to the 5' end of mRNA. Compared to traditional linear mRNAs, circmRNAs can mediate efficient, stable, and durable protein expression and are considered an alternative to linear mRNAs in terms of therapeutic reagents. With the continuous development of circmRNA research, circmRNA has also made significant progress in vaccines and cellular therapies. In this review, we present research advances in the synthesis of circmRNAs, focusing on the biological ligation methods of circmRNAs and current applications, with a summary of challenges regarding circmRNA design, synthesis, and applications. Based on the enhanced stability of circmRNAs, further research on circmRNAs could help expand their applications in biotherapeutics and strengthen their role in basic medical applications.
环状信使核糖核酸（circmRNA）是一种由信使核糖核酸的3'端反向剪接到5'端形成的共价闭环。与传统的线性信使核糖核酸相比，circmRNAs能够介导高效、稳定且持久的蛋白质表达，并且在治疗试剂方面被视为线性信使核糖核酸的替代物。随着circmRNA研究的不断发展，circmRNA在疫苗和细胞治疗方面也取得了显著进展。在本综述中，我们介绍了circmRNAs合成方面的研究进展，重点关注circmRNAs的生物连接方法和当前应用，并总结了circmRNA设计、合成及应用方面的挑战。基于circmRNAs增强的稳定性，对circmRNAs的进一步研究可能有助于扩大其在生物治疗中的应用，并加强其在基础医学应用中的作用。
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