Hospital de Clínicas de Porto Alegre - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil.
Instituto de Cardiologia - Fundação Universitária de Cardiologia, Porto Alegre, RS - Brasil.
Arq Bras Cardiol. 2024 Sep;121(5):e20230293. doi: 10.36660/abc.20230293.
The foramen ovale remains patent in about 25% of the adult population. In adult life, thrombi form in the venous circulation and can cross the interatrial septum and trigger an ischemic stroke - called paradoxical embolism. The treatment can be performed through percutaneous closure of the patent foramen ovale (PFO), but still rarely performed in Brazil because it is not available in the public health care.
To evaluate the reproducibility of clinical trial results in real-life studies due to the low number of records published about the topic.
This study is a retrospective cohort study including 121 patients who underwent percutaneous PFO closure for secondary prophylaxis of ischemic stroke between January 2012 and June 2022.
We observed a mean age of 50.3 years and most females . Severe interatrial shunt was observed in 82.6% and the presence of atrial septal aneurysm in 84.2%. After 6 months of the procedure, no patient still had a residual shunt. There were no serious bleeding or vascular complications. Recurrence of a new cerebrovascular event occurred in 1.6% of patients.
We observed a low recurrence of new ischemic neurological events and lack major complications related to the procedure.
卵圆孔未闭在约 25%的成年人群中仍然存在。在成年期，静脉循环中会形成血栓，这些血栓可以穿过房间隔并引发缺血性中风，即反常栓塞。治疗方法可以通过经皮卵圆孔未闭（PFO）封堵来进行，但在巴西仍很少实施，因为公共医疗保健系统中没有这种方法。
由于关于该主题的记录数量较少，评估真实世界研究中临床试验结果的重现性。
本研究是一项回顾性队列研究，共纳入 121 例于 2012 年 1 月至 2022 年 6 月期间因缺血性中风二级预防而行经皮 PFO 封堵术的患者。
我们观察到平均年龄为 50.3 岁，大多数为女性。82.6%的患者存在严重的房间隔分流，84.2%的患者存在房间隔瘤。术后 6 个月，无患者仍存在残余分流。无严重出血或血管并发症。新发脑血管事件的复发率为 1.6%。
我们观察到新发缺血性神经事件的复发率较低，且与该手术相关的严重并发症罕见。
