Carella F, Girotti F, Scigliano G, Caraceni T, Joder-Ohlenbusch A M, Schechter P J
Neurology. 1986 Jan;36(1):98-100. doi: 10.1212/wnl.36.1.98.
Six patients with different forms of dystonia were treated with gamma-vinyl GABA, a specific enzyme-activated inhibitor of GABA-transaminase, in a double-blind, placebo-controlled crossover study. gamma-Vinyl GABA therapy, 2 g daily for 2 weeks, was compared with placebo by weekly assessments. There were no consistent changes in three evaluation scores. Agents that augment CNS GABA are unlikely to benefit patients with generalized dystonia.
在一项双盲、安慰剂对照的交叉研究中，对6例患有不同形式肌张力障碍的患者使用了γ-乙烯基氨基丁酸（一种γ-氨基丁酸转氨酶的特异性酶激活抑制剂）进行治疗。通过每周评估，将γ-乙烯基氨基丁酸疗法（每日2克，持续2周）与安慰剂进行比较。三项评估分数没有持续变化。增强中枢神经系统γ-氨基丁酸的药物不太可能使全身性肌张力障碍患者受益。
