护士健康研究中阿斯巴甜的摄入与乳腺癌风险
Consumption of aspartame and risk of breast cancer in the Nurses' Health Studies.
作者信息
Romanos-Nanclares Andrea, Schernhammer Eva, Willett Walter C, Holmes Michelle D, Chen Wendy Y, Eliassen A Heather
机构信息
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria.
出版信息
J Natl Cancer Inst. 2025 Apr 1;117(4):795-800. doi: 10.1093/jnci/djae259.
Debate persists regarding the potential carcinogenicity of aspartame, as suggested by experimental studies. Therefore, we prospectively evaluated whether aspartame consumption is associated with breast cancer risk in the Nurses' Health Study (NHS) and NHS II. We used Cox models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). During nearly 30 years of follow-up, with 4 assessments of intake per year, we documented 10 814 invasive breast cancer cases. Overall, there was no association between aspartame consumption and invasive breast cancer risk (HR per 200 mg/d [approximately one 12-oz serving of diet soda] = 1.00, 95% CI = 0.98 to 1.03). We observed similar lack of associations after excluding cases occurring in the first 10 years of follow-up (n = 3125) (HR per 200 mg/d = 1.00, 95% CI = 0.97 to 1.03). In these cohorts, aspartame consumption did not increase breast cancer risk.
正如实验研究所表明的那样，关于阿斯巴甜的潜在致癌性一直存在争议。因此，我们在护士健康研究（NHS）和NHS II中前瞻性地评估了阿斯巴甜的摄入量与乳腺癌风险之间是否存在关联。我们使用Cox模型来计算风险比（HRs）和95%置信区间（CIs）。在近30年的随访期间，每年进行4次摄入量评估，我们记录了10814例浸润性乳腺癌病例。总体而言，阿斯巴甜的摄入量与浸润性乳腺癌风险之间没有关联（每200毫克/天的HR[约一杯12盎司的无糖汽水]=1.00，95%CI=0.98至1.03）。在排除随访前10年发生的病例（n=3125）后，我们观察到了类似的无关联情况（每200毫克/天的HR=1.00，95%CI=0.97至1.03）。在这些队列中，阿斯巴甜的摄入量并未增加乳腺癌风险。
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