Geter R K, Winters R R, Puckett C L
Plast Reconstr Surg. 1986 Jan;77(1):105-15. doi: 10.1097/00006534-198601000-00016.
This two-part study investigated the topical treatment of vasospasm in the tail arteries of rats. In part A, an epinephrine-induced model of vasospasm was used to study a variety of vasodilating agents with actions on at least five different sites in the contractile mechanism of the vascular smooth-muscle cell. The most effective commercially available agents evaluated in this part of the study appeared to be 20% lidocaine and Thorazine (25 mg/ml). In part B, a model was established in which epinephrine-induced vasoconstriction was found to significantly impair anastomotic patency. Thorazine was shown to improve the patency rate of vessels in this setting, and it was found to be superior to 20% lidocaine in improving anastomotic patency.
这项分为两部分的研究调查了大鼠尾动脉血管痉挛的局部治疗方法。在A部分，使用肾上腺素诱导的血管痉挛模型来研究多种血管舒张剂，这些药物作用于血管平滑肌细胞收缩机制中至少五个不同位点。在本部分研究中评估的最有效的市售药物似乎是20%利多卡因和氯丙嗪（25毫克/毫升）。在B部分，建立了一个模型，其中发现肾上腺素诱导的血管收缩会显著损害吻合口通畅性。结果表明，氯丙嗪可提高这种情况下血管的通畅率，并且发现在改善吻合口通畅性方面优于20%利多卡因。
