新生儿皮肤屏障功能的变化：日常变化和沐浴的影响。
Changes in Skin Barrier Function in Neonates: Daily Variation and Impact of Bathing.
机构信息
Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Department of Nursing, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
出版信息
Pediatr Dermatol. 2024 Nov-Dec;41(6):1099-1105. doi: 10.1111/pde.15772. Epub 2024 Oct 17.
BACKGROUND
The skin barrier function is an important predictor of neonatal barrier defects. This study aimed to investigate the daily changes in skin barrier function and the impact of bathing on skin barrier function in neonates.
METHODS
We assessed the transepidermal water loss (TEWL) and stratum corneum hydration (SCH) on the forehead, cheek, volar forearm, and chest from days 2 to 7 and at 1 month after birth. Additionally, we measured the values after bathing and compared them with the pre-bathing values.
RESULTS
Sixty-six neonates were involved in the assessment, and each value at the four sites showed significant correlations. TEWL remained stable between days 2 and 7, but SCH significantly increased at most sites. Both significantly increased by 1.5-2 times in 1 month. After bathing, TEWL increased by more than 20% but decreased again after 3 h.
CONCLUSIONS
TEWL did not change significantly with age during the first week of life. To minimize the effects of bathing, TEWL should be measured at least 3 h after bathing.
背景
皮肤屏障功能是新生儿屏障缺陷的重要预测指标。本研究旨在探讨新生儿皮肤屏障功能的日常变化以及沐浴对皮肤屏障功能的影响。
方法
我们评估了出生后第 2 至 7 天和 1 个月时前额、脸颊、屈侧前臂和胸部的经表皮水分流失（TEWL）和角质层含水量（SCH）。此外，我们测量了沐浴后的数值，并与沐浴前的数值进行了比较。
结果
共有 66 名新生儿参与了评估，四个部位的每个数值均呈显著相关性。TEWL 在第 2 至 7 天之间保持稳定，但大多数部位的 SCH 显著增加。1 个月时，两者均增加了 1.5-2 倍。沐浴后，TEWL 增加超过 20%，但 3 小时后再次下降。
结论
在生命的第一周，TEWL 随年龄的变化不明显。为了将沐浴的影响降到最低，TEWL 应在沐浴后至少 3 小时进行测量。
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